Beruflich Dokumente
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SEMESTER VI
The Federal Food, Drug and Cosmetic Act(FDCA)
by FDA, defines the term “drug” to include “articles
intended for use in the diagnosis, cure, mitigation,
treatment, or prevention of disease in man or other
animals.”
TYPES
HYDROGELS DEGRADABLE
Reduction in frequency of drug administration
Improved patient compliance
Reduction in drug level fluctuation in blood
Reduction in total drug usage
Reduction in drug toxicity
Stabilization of medical condition
Improvement in bioavailability of some drugs
because of spatial control
Economic to health care providers & the patient
Delay in onset of drug action
Requirement of surgery
• Active agents + binders
SUSTAINED • Alter agent’s rate of
RELEASE dissolution/adsorption
• By drug formulation
• Duration/rate of release
is controlled
CONTROLLED • By altering polymer
DELIVERY properties
• Zero order release
Non-
Biodegradable Water-soluble
biodegradable
• Silicone • Polyesters • Naturally
elastomers • Poly(ortho occurring
• Poly[ethylene- esters) polymers
co-(vinyl • Polyanhydrides • Acrylates and
acetate)] • Poly(amino acrylamides
• Polyurethanes acids) • Poly(ethylene
glycol)
Non-biodegradable
Excellent biocompatibility, with only a limited
inflammatory response following implantation.
Ref: Drug delivery- engineering principles for drug therapy by W. Mark Saltzman
Recent development.
Bioactive ceramics like calcium phosphates, glass,
layered double hydroxides, iron oxides etc
They are biodegradable and biocompatible as
well.
Multifunctional -substitute bone tissue
-promote surface reactivity
-act as drug delivery systems