Beruflich Dokumente
Kultur Dokumente
Xi-Shi Liu
- Hyperplastic endometrium
- Better differentiafed
- ER(+),PR(+)
--Less differentiated
--ER(-)PR(-)
--Poor prognosis
Risk Factors
1. Medical conditions
a. Diabetes mellitus, hypertension.
b. Overweight---obesity (excess
estrogen as a result of peripheral
conversion of adrenally derived
androstenedione by aromatization in
fat).
c. Late menopause.
Risk Factors
2. Some gynecologic diseases
( Long-term endogenous estrogen
exposure )
- polycystic ovary syndrome
- functioning ovarian tumors
- anovulating dysfunctional bleeding
- Infertility, Nulliparity.
Risk Factors
3. Prolonged Use of estrogen
a. Prolonged menopausal estrogen
replacement therapy without
progestogen.
• Endometrioid adenocarcinoma
• Mucinous carcinoma
• Serous adenocarcinoma
• Clear cell carcinoma
• Other rare subtypes
Five histological subtypes
--Endometrioid Adenocarcinoma
• Well differentiated.
• Prognosis is better.
Five histological subtypes
--Mucinous carcinoma
• Squamous adenocarcinoma
• Undifferentiated carcinoma
• Mixed adenocarcinoma
Clinical Features--Symptoms
• Asymptomaic (about less than 5% )
– Significances
• Size of lesion
A B
Hysteroscopy
– Significance
-Direct observation
Others
-MRI, CT, chest x-ray, IV urography,
cystoscopy, sigmoidoscopy,
Diagnosis
• Diagnostic methods
Differential Diagnosis
• Direct extension
• Hematogenous metastasis
Clinical Stage
(FIGO 1971)
• Stage I
Stage IIb*
Cervical stromal invasion
Stage IIIa*
Tumor invades the serosa of the corpus uteri and/or
adnexae and/or positive cytological findings
Stage IIIb*
Vaginal metastases
Stage IIIc*
Metastases to pelvic and/or para-aortic lymph nodes
Stage IVa*
Tumor invasion of bladder and/or bowel mucosa
Stage IVb*
Distant metastases, including intra-abdominal metastasis
and/or inguinal lymph nodes
Treatment
• Surgery Radiation
Early stage
--- surge+ postoperative adjuvant therapy
Advanced stage
--- radiation+ surge+ medicine
Principle of choice
• General condition (Age, complication)
• Clinical stage
• Radiation alone
Indications:
– Advanced or recurrent stage
– Early stage and desire for fertility
• Used drugs
– MPA
Chemotherapy
• Advanced stage or recurrent carcinoma
• Used drugs:
– DDP (cisplatin), CTX (cyclophosphamide),
MMC, VP16.
Prognostic Factors
• Tumour bilologic bihavior
– Cell type
– Histological grade
– Depth of myometrium infiltration
– lymph-node metastasis
– Presence of lymph vascular space
involvement
– Positive peritoneal cytology
• General condition
– Old age
– Acute or chronic medical illness
• Choice of treatment
5-Year Survival Rate
• Stage I b: 94%
• Stage I c: 87%
• Stage II : 84%
• Stage III : 40-60%
Follow-up
• 75-95% disease will recur within 2-3 years after
operation.
• Items
– Main complaints
– Pelvic examination
– Vaginal discharge smear
– Chest X ray
– Serum CA125
– Blood routine test
– Blood biochemistry examination
– CT/MRI
Questions
• How to make diagnosis of uterine cancer?