ESTROGENIC EFFECT OF VETIVER ROOT ETHANOLIC EXTRACT

(Veteria zizanoides L.) ON BLOOD LIPID PROFILE IN

OVARIECTOMIZED RATS
 Background
estrogen Solution

Function Deficiency HRT

Vetiver root

• Maintenance of • Cardiovascular
female • Lipid metabolism Side Effect Phytoestrogen flavonoid
reproductive disorder
organs
• Mestrual cycle
isoorintein
Moreira, et. al., 2014
regulatory
• Blood lipid
• Breast cancer
metabolism
• Endometrium cancer
• Stroke
Gustafsson, et. al., 2000
(Rossouw, et. al., 2002
Champagnat, et. al., 2008
1
Program
ESTROGENIC EFFECT OF VETIVER ROOT ETHANOLIC EXTRACT (Veteria zizanoides Kreativitas
L.) ON BLOOD Mahasiswa
LIPID PROFILE 2018 RATS
IN OVARIECTOMIZED
Aim:
Explore the estrogenic activity of vetiver
root ethanolic extracts (VRE) to overcome
lipid metabolism disorders due to estrogen
deficiency.

2
Program
ESTROGENIC EFFECT OF VETIVER ROOT ETHANOLIC EXTRACT (Veteria zizanoides L.) ON Kreativitas Mahasiswa
BLOOD LIPID PROFILE 2018
IN OVARIECTOMIZED RATS
 Method Output
Obtain vetiver root ethanolic
4
1 Maceration
extracts (VRE)

TLC and total flavonoid

2 compound Identify the VRE phytochemical profile

3 In-vivo study in
ovariectomized rat Obtain blood lipid profile of rat

4 Molecular docking
Obtain binding interaction model of
Isoorientin with estrogen receptor

3
Program
ESTROGENIC EFFECT OF VETIVER ROOT ETHANOLIC EXTRACT (Veteria zizanoides L.) ON Kreativitas Mahasiswa
BLOOD LIPID PROFILE 2018
IN OVARIECTOMIZED RATS