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prolactin
By
H.Khorrami Ph.D.
http://khorrami1962.spaces.live.com
khorrami4@yahoo.com
Prolactin
Biologically active
Immunoreactive
Some patients with hi prolactin has no galactorhea
Prolactin
Little 22000mw
Big 50000mw lower activity
Big-big 100000mw lower activity
Glycosylated 25000mw
Prolactin actions
Stimulate learning
Stimulate immune responses
Stimulate opioidergic system
Reduce body temperature
Inhibits libido
Stimulate corticosteroid secretions
Testosterone productions
Maintain LH receptors
Stimulate dopamine turnover in nucleus accumbens
Reduce dopamine turnover in sub. nigra
Prolactin stimulate transcription of mRNA of
Casein
Lactalbumin
Beta-lactoglobulin
Galactosyl transferase
N-acetyl lactosamine synthetase
Prolactin inhibitors
GnRH-associated peptide
Histamine(H2)
Diphenhydramine((H1blocker)
GABA
SST
Ach
Bromocryptine
PIF
Dopamine
GnRH-associated peptide
Prolactin stimulators
TRH Angiotensin II
Oxytocin Bombesin
VIP Secretin
ACTH Gastrin
Beta-LPH Galanin
Estrogen Calcitonin
GnRH Melatonin
GHRH Platelet-activating F
Histamine(H1) Epidermal GF
Cimethidine(H2antagonist) α-MSH
Prolactin increases with
1. Mammogenesis
Estrogen, Progesterone
2. Lactogenesis
Estrogen, Progesterone, prolactin, Placental lactogen,
Growth hormone, Insulin, Cortisol, T3, T4
3. Galactopoiesis
Prolactin, oxytocin