Yusra Pintaningrum

 2006, AHA - Cardiomyopathies are a heterogeneous

group of diseases of the myocardium associated
with mechanical and/or electrical dysfunction that
usually (but not invariably) exhibit inappropriate
ventricular hypertrophy or dilatation and are due to
a variety of causes that frequently are genetic.
Cardiomyopathies either are confined to the heart
or are part of generalized systemic disorders, often
leading to cardiovascular death or progressive heart
failure–related disability.
Braunwald’s Heart Disease, 9th Edition
 Dilated
 Hypertrophic
 Restrictive
 Idiopathic 50 %
 Myocarditis 9 %
 Ischemic heart disease 7 %
 Infiltrative myocardial disease 5 %
 Peripartum 4 %
 HT 4 %
 Other cause (restrictive, familial, valvular,
endocrine, NM, neoplastic and etc. ) 10
%
Braunwald’s Heart Disease, 9th Edition
Patophysiology of Heart Disease, 5th Edition
 Ventricular
chamber
enlargement with
impaired systolic
contractile function

Braunwald’s Heart Disease, 9th Edition

Patophysiology of Heart Disease, 5th Edition

 Idiopathic
 Familial (genetic)
 Inflammatory
 Toxic
 Metabolic
 neuromuscular
Patophysiology of Heart Disease, 5th Edition
 Low forward cardiac output
 Pulmonary congestion
 ECG
 CXR
 Echocardiography
 Cardiac catheterization
 Cardiac MRI
 Relieve symptoms
 Prevent complications
 Improve long-term survival
 Abnormally
thickened
venticular wall
with abnormal
diastolic relaxation
but usually intact
systolic function

Braunwald’s Heart Disease, 9th Edition

Patophysiology of Heart Disease, 5th Edition

 Familial disease
 Mutation within the disease-causing
gene
Patophysiology of Heart Disease, 5th Edition
 Mild Cardiomegaly
 Dyspnea
 Apical Systolic thrill and heave
 Angina Pectoris
 Fatigue
 S4 common
 Syncope
 Systolic murmur >> with valsava maneuver
 Palpitations
 ECG
 CXR
 Echocardiography
 Cardiac Catheterization
 Beta blockers
 Calcium channel antagonists
 Antiarrhytmic drugs
 Surgical therapy (myomectomy)
 With atrial enlargement

Abnormally stiffened
myocardium
(because of fibrosis
or an infiltrative
process) leading to
impaired diastolic
relaxation, but
systolic contractile
function is normal or
nearly normal
Braunwald’s Heart Disease, 9th Edition

Patophysiology of Heart Disease, 5th Edition

 Noninfiltrative

 Infiltrative

 Storage disease

 Endomyocardial disease
Patophysiology of Heart Disease, 5th Edition
 Mild to moderate cardiomegaly
 Dyspnea, fatigue
 Atrioventricular valve regurgitation
 Right-sided congestive heart failure
 Signs and symptoms of systemic disease
(amyloidosis, iron storage disease)
 S3 or S4
 ECG
 CXR
 Echocardiography
 Biopsy
 CT/ MRI
 Symptomatic therapy for all etiologies