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b. patient factors that may hinder adherence, e.g. irregular working hours,
depression, gastrointestinal disturbance, etc,
c. viral factors that will suggest resistance, e.g. acquisition of HIV from a
partner who is on treatment,
1. Co morbidity (e.g., cardiovascular disease, liver disease, viral hepatitis status, psychiatric
disease,renal diseases, or tuberculosis);
2. Patient adherence;
3. Convenience (e.g., pill burden, dosing frequency, food and fl uid considerations);
6. Pregnancy potential;
7. Gender and pre treatment CD4 T-cell count when considering Nevirapine
Adverse Effect of
Antiretroviral
Drugs
Second line treatment
Investigations
Throughout ART
treatment
CD4 Count
Successful therapy is defined as an increment in CD4 cell count that averages
100–150 cells/mm3 per year with an accelerated response in the fi rst 3
months. This is largely due to redistribution .CD4 will increase approximately
100 cells/mm per year for the subsequent few years until a threshold is
reached.1 CD4 counts should be monitored every 3–4 months to:
be performed every 4-6 months once the patient has been stabilized on
therapy.
- Referral to other disciplines as required e.g. dietician, social worker, substance abuse
agencies