Bacterial CAP DR. Justinus Frans Palilingan, dr., Sp.P(K) Diagnosis of pneumonia requires a combination of Clinical assessment, Radiological imaging, and appropriate Microbiological tests.
Plain Chest radiography is an inexpensive test and
is an important initial examination in all patients suspected of pneumonia.
Computed tomography (CT) is a valuable adjunct in
negative or nondiagnostic chest radiography, unresolved pneumonias, and when complications are suspected. Infection of the lower respiratory tract, acquired through the airways and confined to the lung parenchyma and airways, can present radiologically as one of three patterns: (1) focal nonsegmental or Lobar pneumonia, (2) multifocal Bronchopneumonia or lobular pneumonia, and (3) focal or diffuse Interstitial pneumonia.
These patterns can be useful in identifying the causative
organism in the appropriate clinical setting. To serve the purpose of this discussion, these patterns are used as the primary method of classification of pulmonary infections caused by different organisms. Pathologically, Lobar pneumonia is a result of the rapid production of edema fluid with relatively minimal cellular reaction, occurring initially and primarily in the periphery of the lung, then spreading from acinus to acinus through the pores of Kohn and canals of Lambert.
The infection is limited only by pleural boundaries
and eventually by the host's cellular reaction. The quintessential lobar pneumonia occurs from infection with Streptococcus pneumoniae. Lobar pneumonia • Streptococcus pneumoniae • Klebsiella pneumoniae • Legionella pneumophila • Others (aerobic gram-negative bacilli, M. pneumoniae, H. influenzae, S. aureus, SARS, Avian Influenza) Pneumococcal pneumonia Lingular and right upper lobe consolidation Homogenous air space opacification of the left lower lobe (complete lobar consolidation) due to Streptococcus pneumoniae Pneumococcal pneumonia Round pneumonia (S. pneumoniae) Klebsiella pneumonia (PA) Klebsiella pneumonia (lateral view) Klebsiella pneumonia A large cavity in the right lower lobe Klebsiella pneumonia A large cavity in the right lower lobe Legionella pneumonia Legionella pneumophila pneumonia causing lobar enlargement (bulging minor fissure) Legionella pneumophila pneumonia causing lobar enlargement (bulging minor fissure) Legionnaire’s disease Bilateral consolidation SARS SARS AVIAN INFLUENZA AVIAN INFLUENZA Bronchopneumonia Pathologically, bronchopneumonia infections are centered on large inflamed airways with patchy involvement and a subsequent patchy appearance. With the progression of disease, inflamed areas can coalesce, giving rise to a lobar pattern of involvement. Typically, there is an absence of air bronchograms. Because of the destructive nature of the causative organisms that produce this pattern, abscess formation, pneumatocele, and pulmonary gangrene are found commonly. Staphylococcus aureus is a prototypical pathogen causing a radiographic bronchopneumonia pattern. Bronchopneumonia • S. aureus • S. pyogenes • P. aeruginosa • H. influenza • Anaerobic bacteria (aspiration pneumonia) • M. catarrhalis • E. coli Staphylococcal pneumonia with abscess formation Staphylococcal bronchopneumonia A pneumatocele in the right upper lobe Haemophylus pneumonia Widespread small nodular opacities Interstitial pneumonia M. pneumoniae, C. pneumonia, and viral pneumonias typically present as an Interstitial pneumonia.
The chest radiograph demonstrates accentuated bronchovascular
markings and reticular or reticulonodular opacities. The involved region usually does not extend beyond one lobe but the interstitial pneumonia may be diffusely distributed and may progress to a bronchopneumonia pattern. An interstitial pattern can be seen in disseminated fungal and mycobacterial infections. Other bacterial infections may present as an interstitial pneumonia. This is especially true of S. pneumoniae in HIV- infected patients.
Pneumocystis pneumonia (PCP) primarily involves the alveoli but
is usually first seen on the chest radiograph as diffuse bilateral interstitial reticular or reticulonodular opacities. If unchecked the opacities typically progress to regions of air space consolidation that may contain air bronchograms. Mycoplasma pneumonia A patch of left lung consolidation Adenovirus chest Infection Reticulonodullaire, most marked in a bronchovascular distribution at the right base CMV pneumonia Reticular nodular shadowing throughout both lungs Chickenpox pneumonia Widespread predominantly nodular shadowing throughout both lungs Measles giant cell pneumonia Extensive ill-defined opoacities with air bronchograms PCP