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DERMATOLOGY
PRAISY ROY
MPT FINAL YEAR
PSORIASIS:
INVERSE PSORIASIS:
Also called flexural psoriasis
Affects the folds of the skin
Erosive, erythematous plaques and patches
GUTTATE PSORIASIS:
Small erythematous plaques
Acute onset
Affects children or adolescents
Triggered by group – A streptococcal infections
PUSTULAR PSORIASIS:
Multiple coalescing pustules
Affect hands and feet
2 distinct types – 1) psoriasis pustulosa palmoplantaris (PPP)
2) acrodermatitis continua of Hallopeau
Erythrodermic psoriasis:
90% of the body is erythematous and inflamed
Can develop on any kind of psoriasis type
Medical emergency
MANAGEMENT:
Chronic relapsing disease; long term therapy
Categorized into mild, moderate and severe.
Mild: topical treatments, OTC and prescription creams and
shampoos.
Moderate to severe: combination of treatment strategies
1. Topical treatments – glucocorticoids and vit D analogues
2. Phototherapy
3. Systemic medications – inhibitors and immunomodulators
4. Biologic drugs – target specific inflammatory pathways;
administered SC or IV.
PHOTOTHERAPY:
Moderate to severe psoriasis.
Used either on its own or in combination with topical
medicines
Therapeutic regimens:
1. The Goeckerman regimen –
Coal tar applications
Total body UVB radiations
Once a day as suberythemal or E1 dose
2. The Ingram or Leeds regimen –
Coal tar bath before irradiation with MED of UVB
Psoriatic lesions covered with dithranol
Wavelength of 311nm – most beneficial
3. PUVA Therapy –
Psoralen plus ultraviolet A
Involves exposure of the skin to UVA light with usage of
psoralen
4. Balneophototherapy –
Warm water bath containing sea salt or common salt
Exposure to UV light while bathing or immediately afterwards
5. Narrow band UVB phototherapy-
Skin is only exposed to UVB light wavelengths between 311
and 313 nanometers
Reduced risk of side effects
Long term use leads to skin damage and increased risk of skin
cancer.
ACNE VULGARIS:
Inflammatory disorder of the pilosebaceous unit
Affects face, chest, upper arms and back mostly
Hypersensitivity of the sebaceous glands to a normal
circulating level of androgens
Urban populations more affected
Manifestations –
Grade 1: Comedones
Grade 2: Inflammatory lesions present as a small papule with
erythema.
Grade 3: Pustules.
Grade 4: Many pustules coalesce to form nodules and cysts.
Management:
Aim of the treatment – 1) control and treat existing acne lesions,
2) prevent permanent scarring
3) limit the duration of the disorder
4) minimize morbidity
Treatment strategies –
1. Topical treatment – 1) topical retinoids (mild)
2) topical anti-inflammatory agents
3) topical antibiotics
2. Hormonal therapy – OCPs
3. Complementary and Alternative Medicines (CAMs)
4. Laser therapy, light sources and photodynamic therapy
HYPERHIDROSIS:
Excessive sweating
Palmoplantar, axillae, facial, or cervical region
References
Does light therapy (phototherapy) help reduce psoriasis symptoms?
[Internet]. Ncbi.nlm.nih.gov. 2020 [cited 20 January 2020]. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK435696/
Rendon A, Schäkel K. Psoriasis Pathogenesis and Treatment. International
Journal of Molecular Sciences. 2019;20(6):1475.
About Psoriasis | National Psoriasis Foundation [Internet]. Psoriasis.org. 2020
[cited 20 January 2020]. Available from: https://www.psoriasis.org/about-
psoriasis
Sutaria A, Masood S, Schlessinger J. Acne Vulgaris [Internet].
Ncbi.nlm.nih.gov. 2019 [cited 20 January 2020]. Available from:
https://www.ncbi.nlm.nih.gov/books/NBK459173/
Fox L, Csongradi C, Aucamp M, du Plessis J, Gerber M. Treatment Modalities
for Acne. Molecules. 2016;21(8):1063.