Mikroalbuminuria

• Conditions associated with endothelial

damage predispose individuals to
microalbuminuria.
• Microalbuminuria is a risk factor for vascular
disease and nephropathy.
• Endothelial dysfunction precedes
microalbuminuria
• The presence of microalbuminuria implies
dysfunction of the glomerular filtration barrier.
Theoretically, this could result from damage to
any of its layers, including the endothelial
glycocalyx.
 Dipstik
Mikroalbuminuria

• results in 60 seconds
• No 24-hour urine sample
required
• Immunological assay
• Semi-quantitative;
detection levels at
negative, (+) 20 mg/L, (+
+) 50 mg/L, and (+++)
100 mg/L
 METODE PEMERIKSAAN KREATININ

METHOD  ENZYMATIC COLORIMETRIC

H2O2 + 4 aminophenazone + 2,4,6 tri iodo- 3 – hydroxybenzoic acid

POD quinone imine chromogen + H2O
CREATININ PLUS VER 2 (cobas)

Methods Enzymatic colorimetric

No significant interference
Measuring range 1,13 – 452 mg/dl
Expected value
First morning urine
♂ 40-278 mg/dl
♀ 29-226 mg/dl
24 hour urine
♂ 980 - 2200 mg/24 hour
♀ 750 - 1510 mg/24 hour
 Metode Jaffe untuk kreatinin
(IDMS traceable)

Kreatinin + asam pikrat pH alkalis

kompleks kuning-merah

Intensitas warna yang muncul proporsional dengan

kadar kreatinin dalam sampel yang dapat diukur secara
fotometri
 CREATININE JAFFE GEN 2 (COBAS)

Interference Factor
Icterus No significant interference up to bilirubin 50 mg/dl
hemolisis No significant interference up to hemoglobin 1100
mg/dl
No significant interference up to glucose 2100 mg/dl
No significant interference up to urobilinogen 40 mg/dl
Measuring range 0,31 – 367 mg/dl
KONVERSI SATUAN

1 µmol/ l X 0,058 mg/dl

1 mmol/l X 11,3 mg/dl
1 mg/L X 0,1 mg/dl
Rasio kadar ureum darah/kadar kreatinin
darah
•  Normal : Rasio 20 -35 (tiada perubahan
asupan protein) dan tiada penurunan GFR,
• rasio < 20  penurunan kadar ureum
disebabkan penurunan katabolisme protein
atau penurunan redifusi tubular,
• rasio > 35  peningkatan kadar ureum darah
disebabkan oleh peningkatan katabolisme
protein, atau penurunan perfusi tubular
sehingga meningkatkan redifusi ureum