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Leucocytosis
Associated with infection.
Mild leucocytosis is common in RA and during attack
of gout.
The erythrocyte sedimentation rate(ESR)
Increased in acute and chronic inflammatory
disorders and tissue injury.
ESR is affected by presence of monoclonal
immunoglobulin.
High ESR is mandatory in diagnosis of myelomatosis.
C-reactive protein (CRP)
Increased in chronic inflammatory arthritis.
Used to monitor the progress and activity of
rheumatoid arthritis.
Plasma gamma-globulin
Helpful is assessment of rheumatoid disorders , and
in the diagnosis of myelomatosis.
Rheumatoid factor tests
Rheumatoid factor is an autoantibody which is often
present in patients with RA
It is not diagnostic and some patient will remain
seronegative.
It is absent in patients with ankylosing spondylitis ,
reiter’s disease or psoariatic arthritis.
Tissue typing
HLA antigens can be detected in WBC and they are
used to characterize individual tissue type.
Seronegative spondarthritides are associated with
HLA-B27 on chromosome 6.
This is used as confirmatory test in patient having
ankylosing spondyarthritis or Reiter’s disease.
Biochemical tests for metabolic
bone diseases
Serum calcium and phosphate
Should be measured in the fasting state and it is the
ionized calcium fraction that is important.
Vitamin D activity
Assess by measuring the serum 25-HCC
concentration.
Urinary calcium and phosphate
Significant alterations are found in
hyperparathyroidism and malabsorption disorder.