Pharmacological Properties :

MgSO4, methyldopa,
dexamethazone
MgSO4
 Wujudnya Kristal kecil berwarna yang digunakan sebagai -> antikonvulsan, katartik
(memeprcepat defekasi), dan pengganti elektrolit -> pengobatan pre-eklampsia (pencegahan
kejanga) dan eklampsia (mengontrol kejang).
 Pregnancy categorynya : D , continuous long-term use  -> Fetal skeletal demineralization,
hypocalcemia, and hypermagnesemia
 MOA :
 Magnesium sulfate -> reducing acetylcholine release ->  blocks peripheral neuromuscular
transmission ->  reduces striated muscle contractions.
 Magnesium sulfate -> inhibits Ca2+ influx -> relaxant action on vascular smooth muscle.
 Indikasi : • kontraIndikasi :
 control of life-threatening convulsions  Hypersensitivity
-> eclampsia)  Myocardial damage, diabetic coma,
 pre-eclampsia dengan severe heart block
features  Hypermagnesemia
 replacement therapy in magnesium  Hypercalcemia
deficiency,  Administration during 2 hours
 uterine tetany -> myometrial relaxant. preceding delivery for mothers with
toxemia of pregnancy
 Absorption
 Onset (anticonvulsant): IV, immediate; IM, 1 hr
 Duration (anticonvulsant): IV, 30 min; IM, 3-4 hr
 Distribution
 Protein bound: 30%
 Extracellular distribution: 1-2%
 Elimination
 Excretion: Urine
Methyldopa

 alfa-2 yang adrenergik Agonis -> efek sistem saraf pusat dan perifer. -> agen
antihipertensi
 Pregnancy category : B untuk oral, C untuk iv
 MOA :
 Methyldopa -> alpha-methylnorepinephrine -> stimulates the central inhibitory
alpha-adrenergic receptors -> penurunan ympathetic tone, total peripheral
resistance, -> blood pressure
 Methyldopa -> inhibisi  decarboxylin precursor of norepinephrine dan the
precursor of serotonin -> serotonin dan norepinefrine turun -> rangsang
symphatetic turun -> BP turun
 Dosis :  Absorption: 50% for oral
 injectable solution -> 50mg/mL  Protein Bound: Minimal
 Tablet ->250mg & 500mg  Metabolism: Liver

Pharmacokinetics  Excretion: Urine (70%), feces (30-50%)

 Onset: PO 3-6 hr; IV 4-6 hr
 Duration: PO 12-24 hr; IV 10-16 hr
Dexamethazone

 Corticosteroid -> antinflamasi

 MoA -> mempercepat perkembangan morfologi dai sel pneumocytes
(pneumocyte 1 gas exchange, pneumocyte 2 suractant) -> meninkatkan fungsi
paru pada bayi yang lahir preterm
 Indikasi -> usia kehamilan 23-34 minggu yang memiliki resiko kelahiran
preterm
 Dosis -> 5 mg 2x/ hari intramuscular
Pharmakokinetic
 Administration : IV or IM
 Protein binding : 77% protein bound
 Metabolism : liver
 Ekskretion : urin