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SIDE EFFECTS
• Gastrointestinal: anorexia, nausea and
vomitting, diarrhea, stomatitis
• Hypersensitivity: dermatitis, urticaria,
pruritus, fever
• Others: transient hair loss, burning
sensation of feet, bleeding complications
NURSING RESPONSIBILITIES
a. Monitor prothrombin time (PT) daily;
dosage is adjusted to maintain PT at 1.5-
2.5 times normal
b. Obtain careful medication history
c. Advise client to withhold dose and to notify
the physician for signsof bleeding
d. Instruct to use soft toothbrush and to floss
gently
e. Alert client to factors that may affect anti-
coagulant response (high fat diet or
sudden increases in vitamin K-rich foods)
f. Always have vitamin K (antidote for warfarin
toxicity) available at hand.
VARICOSE VEINS
• Dilated veins that occur most often in the
lower extremities and trunk
• Vessels dilate and valves become stretched
and incompetent with resultant venous
pooling/edema
• Most common between ages 30-50
RISK FACTORS
a. Congenital weakness of the veins
b. Thrombophlebitis
c. Pregnancy
d. Obesity
e. Heart disease
ASSESSMENT
SYSTEMIC MANIFESTATIONS
• Pain after prolonged
standing (relieved by
elevation)
• Swollen, dilated, tortous
skin veins
• Leg heaviness and
dependent edema
DIAGNOSTIC TESTS
BRODIE-TRENDELENBURG TEST
• Medical test to determine valvular
incompetence in superficial vein. A finger is
placed over the lower (distal) part of the
vein being examined. The upper (proximal)
part of the vein is then tapped (percussed).
If the impulse is felt by the finger placed at
the lower end, it indicates incompetence of
valves in that vein
• Varicose veins distend very quickly (less
than 35 seconds)
DOPPLER DUPLEX SCAN
ULTRASOUND
• Decreased or no
blood flow heard
after the calf or
thigh compression
NURSING INTERVENTIONS
1. Monitor and improve client’s cardio-
circulatory state – measure circumference
of ankle and calf daily
2. Provide adequate rest
3. Instruct to avoid prolonged standing and
sitting and to change position frequently
4. Elevate legs when tired
5. Provide client health teaching and
discharge planning: same as in
thrombophlebitis
6. Provide dependent and other collaborative
nursing interventions:
a. Apply anti-embolic stockings
b. Prepare client for vein ligation (ligation of
the saphenous vein where it joins the
femoral vein and stripping the saphenous
vein system from groin to ankle)
- provide routine preoperative care
- keep affected extremity elevated above
the level of the heart to prevent edema
- Apply elastic bandages and stockings,
which should be removed every 8 hours for
short periods and then reapplied
- Assist in getting out of bed within 24
hours
- Assess for increased bleeding, particularly
the groin area