COVID-19 DAN PELUANG

BIOTEKNOLOGI DALAM
MENGHADAPINYA

Azzania Fibriani
Institut Teknologi Bandung
COVID-19 GLOBAL PANDEMI
 SARS-CoV-2
Glikoprotein
Nucleopcapsid Membran (M)
(N)

Protein
Spike (S)

Protein
Envelope (E)
Visualisasi SARS-CoV-2
dengan Transmission Materi genetik
Electron Microscope Coronavirus (ssRNA +)
(TEM)
https://microbenotes.com/severe-acute-respiratory-syndrome-coronavirus-sars-cov/
 Alphacoronavirus
Menginfeksi
Mammalia
Betacoronavirus

Coronavirus
Gammacoronavirus
Menginfeksi
burung dan
Deltacoronavirus ikan

Pengelompokkan Virus Corona

 The numbers of base pairs among betacoronaviruses
are shown. This figure is modified from the sequence
The 5′ UTR and 3′ UTR
comparison and genomic organization of 2019-nCoV,
and coding region of 2020.9 The differences in the arrangement of the
COVID-19, SARS-CoV, envelope (E), membrane (M), and nucleoprotein (N)
and MERS-CoV among COVID-19, SARS-CoV, and MERS-CoV are
shown at 3′ end J Microbiol Immunol Infect. 2020 Mar 31. pii: S1684-1182(20)30082-7. doi: 10.1016/j.jmii.2020.03.022
ANALISIS FILOGENETIK SARS-COV2 DARI BERBAGAI NEGARA

Isolat Indonesia

https://nextstrain.org/ncov/asia
 The attachment protein
“spike” of the new
coronavirus COVID-19
andSARS-CoV use the same
cellular attachment factor
(ACE2) and the cellular
protease TMPRSS2 for their
activation.

– Existing, clinically
approved drugs directed
against TMPRSS2 inhibit
SARS-CoV-2 infection of
lung cells.10

J Microbiol Immunol Infect. 2020 Mar 31. pii: S1684-1182(20)30082-7. doi: 10.1016/j.jmii.2020.03.022

SIKLUS HIDUP
VIRUS
CORONA

http://jtd.amegroups.com/article/view/1209/html
PELUANG BIOTEKNOLOGI DALAM
MENGHADAPI COVID-19

Diagnostik
Treatment
Vaksin
Diagnostik untuk deteksi
SARS-COV2 : Realtime
PCR

– Primer dan probe yang spesifik

dirancang untuk deteksi SARS-
COV2
– Produksi enzim rekombinan
– Produksi primer dan probe
– Produksi mesin real-time PCR
Diagnostik untuk deteksi
SARS-COV2 : Rapid test

– Produksi protein antigen rekombinan

– Produksi monoclonal antibodi
– Teknologi biosensor
Treatment SARS-
COV2: Molecular
drug design
Vaccines
SARS-COV2:
mRNA
vaccines
TERIMA KASIH