Keith R. Holden, M.D.

Resonance Center
Jacksonville Beach, FL
www.ResonanceCenterJax.com
 Integrative Biophysics.

 Pulsed Electromagnetic Field (PEMF) Therapy

as an instrument of integrative biophysics.

◦ Biomolecular effects.

◦ Epigenetic effects.

◦ Cellular physiologic effects.

◦ Optimal tissue frequencies.

◦ Proof of efficacy via peer reviewed studies,

including RDBPC clinical trials.

◦ Ondamed® as a powerful instrument of integrative

biophysics.
 Holistic integration of quantum energetic,
molecular, biochemical, and physiologic
processes.
 Reflects the web-like interconnectedness of
all biologic systems within the body and that
of the body with its environment.
 Honors energetic and biochemical
individuality.
 PEMF = instrument for integrative biophysics.
◦ Larmor Precession Model

 External pulsed electromagnetic field matches the

(Larmor) spin frequency of hydrogen atom causing
energized electrons to emit a photon, which act as a
vital energy carrier for tissue repair.

 Ion/ligand binding at cell membrane.

 Alters cascade of biological processes for tissue growth
and repair.
 Amplification of the tissue repair field (current of
injury).
◦ Upregulation of genes involved in normal cell
growth.

(Goodwin, 2003)
 Increases osteoblast intracellular calcium & alters
response to epidermal growth factor.
(Shigaku,1990)

 Stimulates production of type-I collagen, osteocalcin,

& osteopontin.
(Cornaglia, et al., 2006)

 Antiinflammatory effect via restoration of plasma

membrane calcium ATPase activity.
(Selvam, et al., 2007)
  Nerve‐2 Hz
 Bone‐75 Hz
 Ligament‐10 Hz
 Capillaries and skin‐15 Hz

(Sisken, et al., 1995)

(Shupak, 2003)
 Fracture non-union – 65-75Hz
 Congenital pseudoarthrosis – 15Hz
 Osteoporosis – 72Hz
 Hip arthroplasty – 50Hz
 Arthritis – 50Hz
 Tinnitus – 0.5-17Hz
 Rotator Cuff Tendonitis – 71-75Hz
 Venous skin ulcers – 75Hz
 Multiple sclerosis – 4-13Hz

(Shupak, 2003)
Randomized, Double Blind,
Placebo Controlled
 Randomized double blind placebo controlled
(RDBPC) clinical trial.

 PEMF 3X a week for 3 weeks for chronic lower

back pain.

 Significant reduction in pain and disability

over placebo.

(Lee, 2006)
 RDBPC clinical trial.
 Chronic generalized pain from fibromyalgia or
chronic localized musculoskeletal pain.
 PEMF twice daily 40 min. for 7 days.
 PEMF effect over sham for fibromyalgia
approached statistical significance.

(Thomas, et al., 2007)

 RDBPC clinical trial.
 PEMF 30 min. 2X a day for 3 weeks.
 Neck pain, PVMS, and disability scale scores
decreased, and AROM increased significantly in
the PEMF group.
 No change in the sham group.

(Sutbeyaz, et al., 2006)

 RDBPC clinical trial.

 86 patients with OA of knee.

 81 patients with OA of cervical spine.

 Statistically significant improvement in treated

patients for pain and ADLs at end of treatment
and at one month follow up.

(Trock, et al.,1994)
 RDBPC clinical trial.
 Group I (PEMF), Group II (sham PEMF), Group III
(corticosteroid + anesthestic inj.)
 Group III had lower pain than Group I and Group
II at third week.
 Group I (PEMF) patients had lower pain than
Groups II and III at third month.

(Uzunca, et al., 2007)

 RDBPC clinical trial.
 Preclinical studies show that PEMF limits catabolic
effects of pro-inflammatory cytokines on
articular cartilage.
 PEMF 75 Hz 4 hours per day for 60 days.
 Functional recovery occurs earlier with PEMF
group.

(Benazzo, et al., 2008)

 RDBPC clinical trial.

 PEMF 30 min. twice a day for 3 weeks.

 At 12 weeks follow up, PEMF group showed

significant improvements in pain compared to
sham PEMF.

(Sutbeyaz, et al., 2009)

 RDBPC clinical trial.

 PEMF for 90 days 6 hours per day.

 PEMF group statistically significant improvement at
90 days.

 NSAID use – PEMF (26%) & sham (75%).

 3 year follow up, number of patients who completely

recovered was higher in PEMF.

(Zorzi, et al., 2007)

 RDBPC clinical trial.
 PEMF 4 weeks.
 Assessed MSQLI- fatigue, bladder control,
spasticity, & QOL composite.
 Statistically significant improvement in fatigue &
QOL; none bladder control; mixed spasticity.

(Lappin, et al., 2003)

 RDBPC clinical trial.
 PEMF 84 sessions for 30 min.
 WOMAC index dec. 84.1 to 49.7 in PEMF and
73.7 to 66.9 in sham.
 Secondary parameters improved over sham – gait
speed, stride length, & acceleration time.

(Nicolakis, et al., 2002)

 RDBPC clinical trial.

 Active group – 92% success rate.

 Sham group – 65% success rate.

(Mooney, 1990)
 RDBPC clinical trial.

 Refractory rotator cuff tendinitis.

 PEMF showed significant improvement over sham during

the first four weeks.

 No significant difference between groups when both

received PEMF.

 End of study – 65% were asymptomatic.

(Binder, 1984)
CONDITION FDA APPROVED SUCCESS RATE
Fracture nonunion Yes 75-95%
Failed joint fusions Yes 85-90%
Spinal fusions Yes 90-95%
Congenital Yes 70-80%
pseudoarthrosis
Osteonecrosis (hip) No 80-100%
Osteochondritis No 85-90%
dessicans
Osteoporosis No 85-90%
Chronic tendinitis No 85-90%

Chronic skin ulcers No 85-90%

Bassett, CA, Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387-393.
 T mineralization

 T angiogenesis

 T collagen + GAG production

 Endochondral ossification

 (T osteoclasis for pseudoarthrosis)

 T angiogenesis

 T osteoblastic activity
 T angiogenesis

 T collagen + GAG production

Bassett, CA, Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387-393.
 Animal data showing decrease in infarct size.

 Acute affects on blood flow and

angiogenesis.

 Questionable effect on superoxide dismutase

and nitrous oxide.
 Animal data demonstrate decreased growth
and invasiveness of Meth A sarcoma in Balb C
mice, encapsulation and nuclear changes.
 Animal data show decrease in bone
resorption in jaws.

 Increased osteogenesis in tooth extraction

sockets.

 Improved bacterial flora spectrum.

 Clinical benefits on blood glucose reported.

 ? Secondary to Ca++ effects on insulin

secretion.
 Effects on axoplasmic transport.

 Neuronal protein synthesis.

 Ca++/neurotransmitter effects at synapse.

 Angiogenesis.
 Animal data showing improved healing.

 Increased collagen and GAG synthesis.

 Increased angiogenesis.
 Animal data showing increased protein
synthesis.

 Increased axon migration and function.

 No direct evidence.

 Data on neuropathy and nerve transection

may prove beneficial.

 Particularly in crush injuries when sensory

and motor potential evoked potentials are
still present.
 An integrative biophysics instrument that
changes the energetic terrain.

 Positive affects on biologic systems with low

level specific pulsed electromagnetic
frequencies.

 Specific frequencies via pulse testing provide

intelligent information.
 Bassett, CA. Beneficial Effects of Electromagnetic
Fields. J of Cell Biochemistry. 1993; 51:387-393.

 Holden, K. Pulsed Electromagnetic Field Therapy With

the Ondamed – A Tool for Integrative Biophysics.
http://www.ondamed.net/web/publications/articles.
html. 2009.

 Shupak, N. Therapeutic Uses of Pulsed Magentic-

Field Exposure: A Review. The Radio Science Bulletin.
2003 Dec; (307): 9-32.
 Keith R. Holden, M.D.

Resonance Center
496 Osceola Avenue
Jacksonville Beach, FL 32250
(904) 694-0378
krholden@gmail.com

www.ResonanceCenterJax.com