Writing Problem and Hypothesis

Statements for Medical Research(2)

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Setting of work proposal :
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Work problem :
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Quantitative specification of problem :

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Importance of problem :
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Project need : ,
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Work objective : ?
Methodology to achieve objective
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Anticipated results :
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Contribution to field :
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()
Heat shock protein 70 can eliminate waste material from
damaged cells found in stroke patients. However, previous
investigations induced mice to have heat shock protein 70 by using a
hyperthermia procedure, subsequently decreasing the success rate of
related experiments. (NOTE : Add 2-4 sentences that describe
characteristics of the problem or statistics that reflect its severity)
For instance, the accuracy rate of inducing heat shock
protein 70 by using the hyperthermia procedure does not exceed 20%,
accounting for the low success rate of related experiments.
The inability to increase the success rate of inducing mice to
have heat shock protein 70 makes it impossible to understand how
stroke and this protein are related. Therefore, a heat
shock protein 70 inducement procedure must be developed that
contains a statistical database of the mean atrial pressure and brain
pressure for mice responding to this protein, in which their heat shot
responses can be distinguished.
()
A heat shock protein 70 inducement procedure can be
developed that contains a statistical database of the mean atrial
pressure and brain pressure for mice responding to this protein, in
which their heat shot responses can be distinguished.
To do so, heat shot protein 70 can be inserted into the genetic
sequence of mice. This protein can then be observed by comfocal
microscopy. Next, this protein can be examined when the mice incur a
heat stroke. As anticipated, the proposed heat shock
protein 70 inducement procedure can verify that this protein prevents
the degeneration of mice cells by nearly 50%. The face that the mice
carry this protein can also be confirmed. Importantly, the
proposed procedure can facilitate an assessment of whether mice carry
heat shot protein 70, ultimately lowering the extent of harm to stroke
patients. (NOTE : Add 2-4 sentences that describe more thoroughly
how the proposed method contributes to a particular field or sector)
()
With the increasing incidence of acute ischemia strokes in
recent year, computed tomography (CT) or magnetic resonance imaging (MRI)
is used to diagnose its early stages. While diffusion weighted MRI is an
effective means of detecting acute strokes, water diffusion has been introduced
as an additional MRI contrast parameter. While demonstrating the feasibility of
using diffusion MRI to detect acute strokes in early stages, Mosely indicated a
significantly lowered diffusion coefficient in acute stroke areas. This finding has
become an important application of diffusion MRI since conventional MRI has
too low of a contrast for ischemic results, especially in the very early and
potentially reversible phase. As is well known, among the available MRI
approaches, diffusion weighted imaging (DWI) is an important clinical
procedure for diagnosing acute cerebral infarctions. However, the
conventional means of diagnosing acute cerebral infarctions, in which clinical
physicians review the medical history of patients and current conditions as well
as make a subjective assessment in diagnosing stroke cases, normally makes
it impossible not only to diagnose patients with an acute stroke the first time,
but also to identify the type and regional geography of such a stroke accurately.
(NOTE : Add 2 more sentences that describe characteristics of the problem or
statistics that reflect its severity)
()
For some stroke patients, conventionally used
computed tomography methods examine acute brain strokes, whose
acute infraction area has normally extended for over 24 hours.
However, diffusion-weighted MRI examines acute infraction stroke
more effectively than CT does, i.e. up to 6 hours less time during
examination of acute infract strokes. However, when traditional DWI
examination is performed to understand precisely the stroke type and
field range aspect, clinical physicians can only diagnose an acute brain
stroke from an image through visual observation. For instance, a small
infarct has a size of less than 3 mm. The inability to
diagnose an acute infract stroke accurately upon first examination
makes it impossible for clinical physicians to perform gold period grant
medication therapy for stroke patients. Consequently, the therapeutic
outcome is poor, with the extent of brain tissue damage not minimized
to the lowest possible level, possibly losing the opportunity for complete
recovery of functions. Therefore, a quantitative
measurement method must be developed that can reconstruct and
analyze a 3D infarct field range.
()
A quantitative measurement method can be developed that
can reconstruct and analyze a 3D infarct field range.
To do so, patients with an acute infarction stroke having occurred less
than six hours previously can be examined by a clinical physician.
Diffusion-weighted MRI can then be performed to take 2D images. Next,
3D-Doctor software can be composed of a 3D image by each slice of a
2D transverse image. Additionally, the interesting infarct area can be
identified and marked. Moreover, the level of severity for infarct range
can be marked by a darkish color of varying degrees. As
anticipated, the proposed method can identify an infarct area with an
order of severity by classifying grades according to a darkish color of
varying degrees. Moreover, the proposed method can also locate an
infarct area with an order of severity under 60% for purposes of
thrombus dissolution treatment. Importantly, the proposed
method can be used as a standard based on darkish colors of varying
degrees for clinical physicians attempting to determine the proper
dosage amount of medicine. (NOTE : Add 2-4 sentences that describe
more thoroughly how the proposed method contributes to a particular
field or sector)
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