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  • Thermal and Microscopy Analysis

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    indri istiqomah
    8 Ansichten15 Seiten
    The document discusses various techniques for characterizing materials, including thermal analysis methods like differential scanning calorimetry (DSC), differential thermal analysis (DTA), and thermal gravimetry analysis (TGA). It also discusses microscopy analysis methods like light microscopy, hot stage microscopy, electron microscopy, and atomic force microscopy. These techniques are used to determine properties of powders like crystal structure, particle size, shape, surface roughness, and surface chemistry which are important for understanding materials and developing successful formulations.

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    Originaltitel

    13. Thermal and Microscopy Analysis

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    The document discusses various techniques for characterizing materials, including thermal analysis methods like differential scanning calorimetry (DSC), differential thermal analysis (DTA), and thermal gravimetry analysis (TGA). It also discusses microscopy analysis methods like light microscopy, hot stage microscopy, electron microscopy, and atomic force microscopy. These techniques are used to determine properties of powders like crystal structure, particle size, shape, surface roughness, and surface chemistry which are important for understanding materials and developing successful formulations.

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    © All Rights Reserved
    Als PPTX, PDF, TXT herunterladen oder online auf Scribd lesen
    Markieren Sie unangemessene Inhalte
    8 Ansichten15 Seiten

    Thermal and Microscopy Analysis

    Hochgeladen von

    indri istiqomah
    The document discusses various techniques for characterizing materials, including thermal analysis methods like differential scanning calorimetry (DSC), differential thermal analysis (DTA), and thermal gravimetry analysis (TGA). It also discusses microscopy analysis methods like light microscopy, hot stage microscopy, electron microscopy, and atomic force microscopy. These techniques are used to determine properties of powders like crystal structure, particle size, shape, surface roughness, and surface chemistry which are important for understanding materials and developing successful formulations.

    Copyright:

    © All Rights Reserved
    Als PPTX, PDF, TXT herunterladen oder online auf Scribd lesen
    Markieren Sie unangemessene Inhalte
    von 15

    Thermal and

    Microscopy Analysis
    1

    Kuliah Preformulasi 2019


    Characterisation
    Thermal analysis Microscopy analysis

    Crystallographic data Particle properties


    Differential Scanning
    Calorimetry
    Light microscopy

    Differential Thermal
    Analysis
    Hot stage microscopy

    Differential Thermal
    Gravimetry
    Electron microscopy

    Thermal Gravimetry
    Analysis
    Atomic force microscopy

    Kuliah Preformulasi 2019


    2
    Characterisation

    Properties of
    particles
    Manufacturing Properties of Successful Properties of • Size
    processes powders formulation
    crystal/amorph • Shape
    • Surface roughness
    material • Surface chemistry
    • Movement • Crystallographic
    • Blending data
    • Manipulation
    of solids

    Kuliah Preformulasi 2019 3


    Thermal analysis
    DSC DTA

    Kuliah Preformulasi 2019 4


    Thermal analysis
    DTG TGA

    Kuliah Preformulasi 2019 5


    Kuliah Preformulasi 2019 6
    7
    Microscopy analysis

    Kuliah Preformulasi 2019


    Microscopy analysis

    Light Microscopy
    • Transmitted light
    microscopy
    • Reflected light microscopy

    Depends on the sample


    thickness/transparency

    Kuliah Preformulasi 2019 8


    Microscopy analysis
    Hot-stage Microscopy

    • Light microscope +
    temperature controlled stage
    • Visualizing DSC thermogram
    • Visualizing TGA thermogram
    seen as bubbles release.
    • Coupled with cross
    polarizing filters to capture
    the birefingent of
    crystal/polymorphs

    Kuliah Preformulasi 2019 9


    Microscopy analysis

    What is
    birefringence?
    Why some samples
    show
    birefringence?

    Kuliah Preformulasi 2019 10


    Microscopy analysis
    Electron microscopy

    • Shorter wavelength than


    light microscope
    • Electromagnet used to
    capture the electron beams
    • Transmission electron
    microscope
    • Scanning electron
    microscope

    Kuliah Preformulasi 2019 11


    Microscopy analysis

    Atomic force microscopy

    • Deflection of a cantilever back


    to build up a topographical
    image of sample surface

    Kuliah Preformulasi 2019 12


    Particle size
    Coulter counter

    • Based on the change in conductivity of an


    electrolyte as particles in suspension are drawn
    through an aperture. Particles assumed as
    spherical

    Photon correlation spectroscopy

    • Dispersed powder in liquid/air placed in a parallel


    beam of laser light.

    Sieve analysis

    Microscopy

    Kuliah Preformulasi 2019 13


    Particle size

    Irregular particle
    shape’s size measure
    Histogram

    Limitation: not
    representative

    Kuliah Preformulasi 2019 14


    Solid properties
    Molecular • Stability
    packing • Dissolution rate

    • How to process the material


    Particle shape • Habit determined by visualization by microscope

    Surface • Topography and surface energy


    properties • Determined by atomic force microscopy

    Particle size
    distribution
    Kuliah Preformulasi 2019 15

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