BIOSENSORS:

Submitted by:

Guided by:

Shweta Sain
Department of Electronics & Communication

Mr. S.D. Vyas

Assistant Professor

6/18/2011

Evolution of Biosensors:
Analytic C emistry is t e analysis of material samples to gain an understanding of t eir c emical composition, structure and function.
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Spectroscopic analysis Electroc emical analysis Mass analysis T ermal analysis Separation science Data Acquisition and analysis Hybrid tec niques

Department of Electronics & Communication

W at is a Biosensor?
A biosensor is an analytic device for t e detection of an analyte ; intimately associated it or integrated it in a p ysioc emical transducer or transducing microsystem.

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Department of Electronics & Communication

Elements of a Biosensor:

T e biocatalyst (a) converts t e substrate to product. T is reaction is determined by t e transducer (b) ic converts it to an electrical signal. T e output from t e transducer is amplified (c), processed (d) and displayed (e).

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Department of Electronics & Communication

Outline of a Biosensor System:

Principle & Construction

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Department of Electronics & Communication

Outline of a Biosensor System:

Mat ematical Basis

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Department of Electronics & Communication

Outline of a Biosensor System:

Application & Data Display

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Department of Electronics & Communication

Basic C aracteristics:
BIOSENSORS

LINEARITY

RESPONSE TIME

SENSITIVITY

SELECTIVITY

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Department of Electronics & Communication

Classification:

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Department of Electronics & Communication

Recent Trends:
Medical Telesensors Microcantilevers Bioreporters Miniaturized devices

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Department of Electronics & Communication

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Lab on a C ip:
Aim of t e development of Lab-on-a-c ip system is performing all stages on a c ip. Lab-on-a system consists of; Microc anells and micropumps Sample pretreatment units Reservoir for probes, substrates, buffers and ot ers DetectorsSampling more t en one analyte or sample at t e same time
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A promising approac :
Glucose monitoring in diabetes patients istorical market driver Ot er medical ealt related targets Environmental applications e.g. t e detection of pesticides and river ater contaminants Remote sensing of airborne bacteria e.g. in counter-bioterrorist activities Detection of pat ogens Determining levels of toxic substances before and after bioremediation Detection and determining of organop osp ate Routine analytical measurement of folic acid, biotin, vitamin B12 and pantot enic acid as an alternative to microbiological assay Determination of drug residues in food, suc as antibiotics and gro t promoters, particularly meat and oney. Drug discovery and evaluation of biological activity of ne compounds. Protein engineering in biosensors Detection of toxic metabolites suc as mycotoxins

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References:
.karstenfae nric .de .jaist.ac.jp Biosensor Systems by .axiom-j.co.jp .ufz.de Optical biosensors in drug discovery by Matt e A. Cooper, .nature.com .lsbu.ac.uk , by K Bruce Jacobson . ikipedia.org ttp:// .cranfield.ac.uk/biotec /sensors/ istory. tm ttp:// .ornl.gov/info/ornlrevie /rev29_3/text/biosens. tm T e International Journal on Biosensors and Bioelectronics . Vo-Din , T. Alarie, J.P. Isola, N. Landis, D. Wintenberg, A.L. Ericson, M.N. Anal C em 71, 358 363 (1999). ttp:// .p armainfo.net/revie s/application-nanobiosensors-and-bioc ips- ealt -care-revie

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T ank you

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Department of Electronics & Communication

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