Beruflich Dokumente
Kultur Dokumente
True or false?
Participants might get HIV from the vaccine being tested. There is already an effective HIV vaccine, but its being deliberately withheld. Vaccines are intended to cure people with HIV. If someone volunteers in an HIV vaccine trial, it means they have HIV. Researchers test HIV vaccines by administering the vaccine and then exposing the participants to the virus. Researchers try to get participants to engage in highrisk behavior so that they get exposed to the virus.
Discovery
Clinical Research
Does it work?
Participants
20-100 people
100-200 people
thousands of people
Risks of Participation
Like most vaccines, the HIV vaccines used in clinical trials may cause side effects, such as: Soreness at the injection site Low-grade fever Body aches
Side effects tend to go away quickly on their own No long term side effects have been identified in HIV vaccines tested to date
Vaccine-induced seropositivity
HIV vaccines are designed to provoke immune responses this includes antibody production
Standard tests for HIV detect antibodies, not virus Study participants who receive HIV vaccines will often test positive (seropositive) on these standard tests but it doesnt mean they are HIV-infected
HVTN 505 enrollment begins First HIV vaccine trial opens Results of Phase III Thai Trial (RV144)
1980
1990
2000
2010
HIV identified
True or false?
Participants might get HIV from the vaccine being tested. There is already an effective HIV vaccine, but its being deliberately withheld. Vaccines are intended to cure people with HIV. If someone volunteers in an HIV vaccine trial, it means they have HIV. Researchers test HIV vaccines by administering the vaccine and then exposing the participants to the virus. Researchers try to get participants to engage in highrisk behavior so that they get exposed to the virus.
BeTheGeneration.NIH.gov
2003 2004 2005 2006 2007 2008 2009 2010 2011 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 RV 144 Merck 023/HVTN 502 (STEP) HVTN 503 PAVE 100
Enrollment Follow-up
PAVE 100
STEP RV 144
HVTN 503
2003 2004 2005 2006 2007 2008 2009 2010 2011 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 1 2 3 4 RV 144 Merck 023/HVTN 502 (STEP)
HVTN 503
PAVE 100
Enrollment Follow-up
HVTN 503
HVTN 505
PAVE 100
STEP RV 144