Top 10 Myths and Facts about HIV/AIDS

S. Wakefield, Director External Relations HIV Vaccine Trials Network (HVTN)

National Press Foundation August 2011
The HVTN is supported through a cooperative agreement with the National Institute of Allergy and Infectious Diseases

RECOGNIZE AND RESPOND

Previously in the world of HIV prevention.

Carl W. Dieffenbach, Ph.D. Director Division of AIDS, NIAID

No Consensus on Impact of Circumcision in MSM

Circumcision Status and HIV Infection Among Black and Latino Men Who Have Sex With Men in 3 US Cities
GA Millet et al.

Circumcision and HIV Seroconversion Among Men Who Have Sex With men in 6 US Cities
SP Buchbinder et al.

N = 2,235 Cross-sectional Data No evidence that being circumcised was protective against HIV infection among black or Latino MSMs

N = 3,257 Cohort Study with Majority White MSMs (~19% black and Latino) Evidence of a 2-fold reduction in HIV Seroconversion with Circumcision

Previously in the world of HIV vaccine news

VaxGen Lesson Misinformation

Media Coverage

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Myths and Facts about HIV/AIDS

Casual Contact
HIV Can Be Spread Through Tears, Sweat, Mosquitoes, Swimming Pools ... Toilet seat, Coughing, Restaurant, Mosquito bites, Kissing

www.thebody.com

Internet Resources Abound

Check mark equals myth
I dont have permission for all images contact wakefield@hvtn.org and I will remove at your request

Disease of Other People

HIV and AIDS only affects gay men and drug users and people in Africa

Most PLWHIV are Heterosexuals

Ask why next Thai trial will be conducted in MSM (men who have sex with men)

Namibia, Botswana, Malawi No data on MSM these High HIV prevalence countries
Dr. Chris Beyrer - Hopkins

Death Sentence?
I have just been diagnosed with HIV and AIDS...I am going to die.

People are living well and having sex!

Research continues to unravel the mystery of the HIV virus

Partnership Definitions Are Changing

Understanding Regarding the Link Between Behavior and Biomedical Research IsChanging

Scientific Challenges Already Have One Challenge

Finding and HIV vaccine should be easy!

HVTN Achievements
Clinical Research

Laboratory

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Med Ad5 Titer

Low Med Ad5 TiterTiter Ad5

Analytic/Design

*p<10-6, 1 way ANOVA

Up-regulated Down-regulated

HVTN Pipeline

Evaluate vaccines & understand immune responses

38 Phase I 3 Phase II 15 other studies
HIV Infection Trials Tissue and Fluid Projects Innate Immunity Peru circumcision Population
Adolescents At risk women Twins

Research has provided over 30 treatments for HIV+ persons

Once-A-Day Treatments New Class of Medications CCR5 Inhibitors New Class of Medications Integrase Inhibitors

Berlin Patient
HIV and AIDS can be cured. HIV and AIDS can be cured.

May 2008 Headlines

At Front Lines, AIDS War Is Falling Apart As the Need Grows, the Money for AIDS Runs Far Short After Long Scientific Search, Still No Cure for AIDS

What do the Thai trial results mean?

HIV Medicine is A Specialty

My family doctor can treat my HIV and AIDS.

Two Posters Legacy Project Faith Initiative & Project Vogue

HIV Medicine is A Specialty

You Can't Have a Baby if You're HIV Positive

Test Results May Differ For Persons in HIV vaccine study

An HIV test will tell me if I have AIDS

How Are Most Vaccines Made

Epi

April 2010

Live attenuated vaccines(example s: measles, mumps, and rubella) Whole killed virus vaccines (example: influenza and rabies)

Can this Vaccine give me HIV?

NO!
The HIV vaccines being tested are made from synthetic pieces of HIV. Therefore, the vaccine CANNOT cause infection.

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Our Universe

When We Achieve Our Ultimate Goal

An HIV vaccine will be given once; protection lasts a lifetime Durable protection is conferred to the person at risk An effective vaccine is among the most cost-effective medical interventions