Beruflich Dokumente
Kultur Dokumente
Number of Citations
2. Is the presence of CRP associated with CAD? Cohort, and Case
8 Control
Setting. Wichita State University utilizing the library and online electronic resources. Results: C-Reactive Results: The presence of
6
Protein is a Marker of C-Reactive Protein is Background
Study population. A literature review was performed using the search engine of peer- Inflammation Associated with Coronary Information
reviewed articles obtained from Medline utilizing specific key terms including C-reactive n=52 Artery Disease 4
protein, coronary artery disease, inflammation, atherosclerosis, vessel injury, marker, (4 articles having 2 group n=26 Not Specified
history, and underlying cause. Articles were selected based on their content associated classifications) (2 articles having 2 group 2
with CRP and CAD. classifications)
0
Study design. Systematic evidence-based literature review from peer-reviewed articles Grade of Evidence
published in journals that addressed the issue of CAD and CRP. Outcome: C-Reactive Protein is a Marker of
Inflammation and Associated with
Measurements. Articles were categorized into levels of evidence and separated into Coronary Artery Disease
categories to answer the two main research questions. Data was placed into organized CONCLUSIONS
n=24 Articles The purpose of this study was to determine the validity of CRP as a marker for
tables utilizing Microsoft Excel. Column classifications include Study (year), Groups of
Evidence (I-VI), Number and Characteristics, Pertinent Findings, Valid Marker (Y/N), and inflammation and to determine its association with CAD. C-Reactive Protein is a
Associated With (Y/N). RESULTS superior marker for inflammation and plays a pivotal role in the atherosclerotic process.
Data collection. Upon completion of organized tables, data were evaluated based on the Study Findings. Fifty percent (n=24) of the articles that met inclusion criteria answered
both question one and two. Eleven articles met Grade A evidence, which is the
number of articles that answered the two main research questions. Calculations were REFERENCES
determined based on number of articles meeting criteria divided by total number of highest strength of recommendation3. Refer to Figure 2 for graphic representation.
• Tendra M. J Renin Angiotensin Aldosterone System. 2004 Sep; 5 Supplement 1:S2-6.
articles. This procedure was performed with group I-VI evidence classification • Ridker P. The New England Journal of Medicine. 2002 Nov; 347(20):1557-1565.
(I:random/control; II:retrospective/prospective cohorts; III:case control; IV:cross sectional; Completed Research Studies. In the Fragmin and Fast Revascularization during In
• Ebell M. American Family Physician. 2004; 69:549-57.
V:backgrouond information; VI:not specified in literature), grades of evidence (A:group I-III
evidence; B:group IV evidence; C:group V evidence; D:groupVI evidence), research
Stability in Coronary artery disease (FRISC) study group, factors such as troponin T,
CRP, and fibrinogen were evaluated in patients with unstable angina due to their
•
•
Lindahl B. The New England Journal of Medicine. Oct; 343(16):1139-1147.
Ridker P. Circulation. 2003; 107:r20-r26.
question one, and research question two. One research diagram and three bar graphs • Verma S. Circulation. 2002 Apr; 105:1890-1896.
were created using data collected from calculations. Refer to Figure.1 for diagram.