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VACCINE
INTRODUCTION
Definition
Vaccine may lived or weakened strains of
viruses or bacteria which intentionally give
rise to in apparent to trivial infections
Vaccines may also be killed or inactivated
organisms or purified product derived from
them
INTRODUCTION
Vaccines involves deliberate exposure to
antigen under condition where disease
should not result.
It
should induce antibody formation in the
body
TYPES OF VACCINES
A. Traditional vaccines
(i) inactive (killed) vaccine
(ii) attenuated vaccine
(iii) Subunit vaccine
:
Recombinant vaccine
Subunitvaccine
Gene deleted vaccine
Vectored virus vaccine
Other
Subunit vaccine
A subunit vaccine contains only the proteins which
stimulate the immune system to attack.
By manipulating DNA that codes for these most
stimulatory proteins, we can mass produce a purified
solution and immunize with only the antigen we want
and no extraneous antigens.
Eg. The Genitival brand of Feline Leukemia Vaccine
(not currently on the market) is an example of a
subunit vaccine
Gene deleted vaccine
Description-
Hepatitis B Vaccine (Recombinant) is a non-
infectious subunit viral vaccine derived from hepatitis
B surface antigen (HBsAg) produced in yeast cells. A
portion of the hepatitis B virus gene, coding for
HBsAg, is cloned into yeast, and the vaccine for
hepatitis B is produced from cultures of this
recombinant yeast strain according to methods
developed in the Merck Research Laboratories.
Vaccine must contain antibody against surface
antigen(HBV Ag)
It was first made from the serum of people who had
been HBV infected and subsequently cleared the
infection. Because these individuals naturally
produced anti-HBsAg IgG and then cleared the
infection, they were immune to reinfection with HBV.
The serum from these individuals was taken and
purified antibody was passively administered to
others in order to induce immunity
Recombinant tec.