Beruflich Dokumente
Kultur Dokumente
Primary secretary products of GIT are: Digestive enzymes GI-hormones Mucous Electrolytes, HCl, NaHCO3 GIT secretary glands 1. Goblet cells: mucous producing glands 2. Brunners gland: mucous glands 3. Crypts of Lieberkuhn: water and electrolytes 4. Gastric glands: Oxyntic, pyloric and mucous glands 5. Complex glands: salivary, pancreatic glands and liver 6. Enteroendocrine cells: produce hormones 7. Others: Panet cells, APUD cells, chromaffine cells
Salivary secretion
Produced by 3 pairs of salivary glands Average salivary out put is 800 1500 ml/day Salivry pH = 6.0 -7.4 Ionic composition: K+, HCO3, Na, Cl The primary secretion contains ptyalin, mucous and ECF Active secretion of K & HCO3 in the duct Active reabsorption of Na & Cl in the salivary duct
Function of saliva
Moistening the mouth and aids speech Keeps oral hygien, contains bacteriocidal substances: thyocyanide, lysozymes Lubricates food and assissts swallowing Buffers suden change of oral pH Xerostomia Dry mouth due to insufficient salivary production
4
GPN
Parotid
+
Taste Touch Temperature FN
FN
VN
SMG SLG
Saliva
Cephalic Phase
Excitatory events include: Sight or thought of food Stimulation of taste or smell receptors Inhibitory events include: Loss of appetite or depression Decrease in stimulation of the parasympathetic division
10
Gastric Phase
Excitatory events include: Stomach distension Activation of stretch receptors (neural activation) Activation of chemoreceptors by peptides, caffeine, and rising pH Release of gastrin to the blood Inhibitory events include: A pH lower than 2 Emotional upset that overrides the parasympathetic division
11
Intestinal phase
Excitation low pH partially digested food enters the duodenum and encourages gastric gland activity Inhibition distension of duodenum presence of fatty, acidic, or hypertonic chyme, and/or irritants in the duodenum Initiates inhibition of local reflexes and vagal nuclei Closes the pyloric sphincter Inhibit gastric secretion
12
13
14
3. K+ is diffused into the lumen and Na+ enters the parietal cells and H2O moves into the lumen by osmosis Parietal cells secrete 160 mmol/L of HCl, pH = 0.8, 3 million x that of blood pH Carbonic anhydrase (CA) inhibitor = acetazalamide
H+
CA
15
Enteroendocrine cells
G-cells = secret gastrin S-cells = secret secretin I-cells = produce CCK EG-cells = enteroglucagon and GLP Gland-cells = GIP and VIP D-cells = Somatostatin Other cells = motilin, substance-P
19
20
21
The Pancreas
Pancreas Location: Lies deep to the greater curvature of the stomach The head is encircled by the duodenum and the tail abuts the spleen Divided into: Head, body and tail Connected to the duodenum via the main pancreatic duct (duct of Wirsung) and accessory duct (duct of Santorini). Pancreas contains two types of secretary glands: 1. Endocrine cells (islets of Langerhans) secrete hormones and 2. Exocrine cells (acinar cells): secrete a mixture of fluid rich in NaHCO3 and digestive enzymes called pancreatic juice.
Pancreatic Activation
24
27
28
Bile leaves the liver via: Bile ducts, which fuse into the common hepatic duct The common hepatic duct, which fuses with the cystic duct These two ducts form the common bile duct
29
31
Functions of Liver
3. Protein Metabolism Deamination of amino acids = removes NH2 (amine group) from amino acids so can use what is left as energy source Converts resulting toxic ammonia (NH3) into urea for excretion by the kidney Synthesizes plasma proteins utilized in the clotting mechanism and immune system Convert one amino acid into another
33
Secretion of bile
Bile is secreted by hepatocytes in the liver for two purposes 1. It facilitates fat digestion and absorption in the SI 2. Serves as a means of excretion of waste products (bilirubin and cholesterol) Bile secretion has two stages: 1. Primary secretion: contains bile salt, cholesterol, lecithin, electrolytes (Na, Ca, K ions) 2. Secondary secretions: contains primary secretions plus water, NaHCO3, K, Cl. Average biliary out put: 600 -1200 ml/day is secreted by the liver yellow-green in colour b/c of bilirubin & pH = 7.6 - 8.6 Components water & cholesterol bile salts: Na & K salts of bile acids bile pigments (bilirubin) from hemoglobin molecule heme: broken down into iron and bilirubin globin: a reusable protein
35
Storage of bile
Stored in the GB GB can accommodate 20 to 60 ml of bile GB mucousa can absorb water, Na, Cl, K but not Ca, cholesterol bile salts and fats.
36
Bile secretion
37
38