Beruflich Dokumente
Kultur Dokumente
BIOLOGY 25
LECTURE
A. Santiago
Lecture Content
• Capillary transport of O2 and CO2
(as a continuation of respiration)
• Cardiac Physiology
– Cardiac muscle structure
– Cardiac action potential & conduction system
– Cardiac cycle, EKG & arrhythmias
– Cardiac Output
• Vascular Physiology: Dynamics of blood circulation
• Urine Formation: Ultrafiltrate of Blood
• Blood Pressure and Urine Formation
2
1.5%
O2 Transport 98.5%
3
O2 Transport
4
O2 –Hb Dissociation Curve
5
Shifting the Curve
6
CO2 Transport and Cl- Movement
7-10%
20-30%
60-70%
Conten
t
7
Cardiac Muscle
8
Electrically,
cardiac muscle
behaves as
single unit
9
10
Orientation of cardiac muscle fibers
12
Cardiac Muscle Refractory Period
15
Heart contraction steps
Conten
t 16
Cardiac Cycle
• Heart is composed of two pumps that work
together: the right and left halves
• Repetitive contraction (systole) and relaxation
(diastole) of heart chambers
• Blood moves through the circulatory system
from areas of higher to lower pressure.
– Contraction of heart produces the pressure
17
18
Heart sounds
• First heart sound or “lubb”
– Atrioventricular valves and
surrounding fluid vibrations as valves
close at beginning of ventricular
systole
• Second heart sound or “dupp”
– Results from closure of aortic and
pulmonary semilunar valves at
beginning of ventricular diastole,
lasts longer
• Third heart sound (occasional)
– Caused by turbulent blood flow into
ventricles and detected near end of
first one-third of diastole
19
EKG
20
Cardiac Arrhythmias
24
Stroke Volume: Afterload
↑afterload
↑ myocardial O2 demand
↑ work of the heart
Pulmonary vascular resistance
(PVR):
right ventricle afterload
(800-1200 dynes/sec/cm-5)
Systemic vascular resistance (SVR):
left ventricle afterload (~1/6th of
PVR)
(100-250 dynes/sec/cm-5)
25
Contractility
Conten
t 26
Dynamics of Blood Circulation
• Interrelationships between
– Pressure
– Flow Poisseuille’s Law
– Resistance
– Blood flow through vessels
27
Poiseuille’s Law: Pressure, Blood Flow and Viscosity
∆P = (Pa – Pv)/R
Vascular resistance
(PVR and SVR)
Cardiac output
MAP = (CO ⋅ SVR) + CVP (eq. 1)
Because CVP is usually at or near 0 mmHg,
this relationship is often simplified to:
MAP approx = CO ⋅ SVR (eq. 2)
Central Venous
Pressure
29
Vascular Cross-Sectional Area
• As diameter of
vessels decreases,
the total cross-
sectional area
increases and
velocity of blood flow
decreases
• Much like a stream
that flows rapidly
through a narrow
gorge but flows
slowly through a
broad plane 30
Blood volume distribution among vessels
31
Laminar and Turbulent Flow
• Laminar flow
(normal)
– Streamlined
– Outermost layer
moving slowest and
center moving fastest
• Turbulent flow
– Interrupted
– Rate of flow exceeds
Arteriosclerosis (vessels
less elastic due to aging) critical velocity
– Fluid passes a
constriction, sharp
turn, rough surface
32
Nervous Innervation of
the Heart & Blood Vessels
33
34
Urine Formation
1. Filtration
Initial Urine = blood plasma – proteins and cells = urea,
uric acid, glucose, water, vitamins, amino
acids
4. Reabsorption
Filtrate interstitial fluid peritubular capillaries
blood system
6. Secretion
Blood system peritubular capillaries interstitial fluid
filtrate
35
36
Blood Pressure & Urine Formation
37
Renin-Angiotensin-Aldosterone
Mechanism
38
Vasopressin (ADH) Mechanism
39