A Perspective On Minerals and Metals in Human Health

A Perspective on Minerals & Metals in Human Health
Bradford S. Weeks, M.D. www.weeksmd.com md@weeksmd.com
Dedication:
Richard Kunin
& Paracelsus Alterius non sit qui suus esse potest
~ Let no man that can belong to himself be of another
Bradford S. Weeks, M.D. (c) 2009
Everything fails me every thing These instruments, do they not all Mock me? Lathe, cylinder, and ring, And cog and wheel in vain I call On you for aid, ye keys of Science, I stand before the guarded door Of Nature; but it bids defiance To latch or ward: in vain I prove Your powers, the strong bolts will not move.
Faust, in his study, before the deal
Mysterious, in the blaze of day, Nature pursues her tranquil way: The veil she wears, if hand profane Should seek to raise, it seeks in vain, Though from her spirit thine receives, When hushed it listens and believes, Secrets revealed, else vainly sought, Her free gift when man questions not,__ Think not with levers or with screws To wring them out if she refuse.
Definitions
Element - a type of atom that is distinguished by its atomic number (the number of protons in its nucleus). The term is also used to refer to a pure chemical substance composed of atoms with the same number of protons. Mineral - a naturally occurring homogenous substance with a crystalline structure and defined chemical composition formed as a result of geological process. Metal a lattice of positive ions surrounded by a cloud of delocalized electrons. They are one of the three groups of elements as distinguished by their ionization and bonding properties, along with the metalloids and nonmetals. They rarely found in pure form in nature
Lithium #3 in the periodic table = 3 protons

- lightest metal, - highest specific heat of any solid metal so used in heat transfer technology relieves hotheadedness mania
Element Lithium Beryllium Boron Carbon Nitrogen Oxygen Fluoride
A# 3 4 5 6 7 8 9
Qualities Lightest metal, a dense as water, highest specific heat, transfer use Toxic, used in nuclear reactors, low thermal neutron absorption Natural fiber optic and transmits infrared light Hexagonal crystal, obtained from buring with insufficient oxygen; Derives only from life forms 78% of air, carrier of astrality, universes 5th most abundant element; allergen yet inert as gas, cryo L Oxy genes (GR acid forming), fire air 1/2 earth crust, 2/3 of you 9/10th of water , 3rd in Universe; Most electronegative and reactive of all elements; used in producing uranium, waste to water supply
Element Hydrogen Lithium Sodium Potassium Rubidium Cesium
A# 1 3 11 19 37 55
Qualities Gr Hydro genes= water forming most abundant element in universe; star fuel; saturates C Lightest metal, a dense as water, highest specific heat, transfer use Med Latin sodanum headache remedy, ignites on contact with water; burns yellow KCL fertilizer, KOH soap K nitrate, flash on matches Byproduct of refining lithium, spectroscope deep red; liquid at room temp, ignites H and O, blend w Hg Au Spectroscope blue (L caesius = blue sky), melting pt 83 deg F in your hand, beer brewing, (watch K)
Francium
87
Last naturally occurring element discovered, 30 g on earth at one time; radioactive; (Astatine is rarest)
Irridium 77 - 2nd densest element, least corrosive, siderophilic, meteorites, dinosaur extinction;
Platinum 78 - alchemical symbol joined Ag and Au catalytic converters, missile cones, chemo Rx Gold 79 most malleable: 1 oz -> 5 meters sq; 400x thinner than a human hair = 0.000127mm Mercury 80 - one of 6 elements liquid at room temp and the only metal,
Titanium 81 - 9th most common earth element, stronger and lighter than steel, non-corrosive with salt water, human tissue, only element than burns in pure nitrogen;
Egyptian signs for the Elements
Alchemical and chemical symbols in Nicolas de Locques Les rudimens de la philosophie naturelle, Paris 1655.
Elements 1. Oxygen. 2. Hydrogen. 3. Nitrogen. 4. Carbon. 5. Sulphur. 6. Phosphorus 7. Gold. 8. Platinum. 9. Silver. Chemical Symbols used by Dalton
19th century
10. Mercury. 11. Copper. 12. Iron. 13. Nickel. 14. Tin. 15. Lead. 16. Zinc. 17. Bismuth. 18. Antimony.
Compounds.
37. Water. 38. Hydrofluoric acid. 39. Hydrochloric acid. 40. Chloric acid. 41. Nitric oxide.
Alum
Frontpiece Woodcut of the celestial Woodcut from William Cuningham sphere by Erhard Schn, 1515. The cosmographical glasse, 1559 Bradford S. Weeks, M.D. (c) 2009
Definitions cont.
It is far easier to define something than it is to know it. When we name something we demystify it and have dominion over it.
Which box are you thinking outside of?

Knowing and Thinking

In medicine, you need to know nothing but you need to be able to think. Otto Wolff, M.D.
Engraving from Baro Urbigerus Besondere chymische Schrifften, 1705.
Frontispiece engraving from 1774 Drey curieuse chymische tracttlein
Many have said of alchemy, that it is for the making of gold and silver. For me such is not the aim, but to consider only what virtue and power may lie in medicines. Paracelsus
Golden Moments
Year 1382 1586 1602 1648 1667 1701 1709 1716 1782 Date Apr 25 5pm Dec 19 Mar 13 4pm Jan 15 Jan 19 10am Oct 1 8pm Feb 16 eve Dec 31 May 25 Alchemist N.Flamel NS Kelly NS A.Seton Richthausen Helvetius Bttger Lascaris J. Price Metal Hg Hg Pb Hg Pb Ag Hg Pb Hg Place Paris Bohemia Amsterdam Prague The Hague Germany Germany Rhineland Guildford
Metals are condensed vapors from the various planets which were trapped when earth solidified from a gaseous state to its solid state. When you hold a metal in your hand, you are holding the forces of its planet also.
paraphrase Rudolf Steiner Occult Science

Metallic Presence in Humans

Element
Mg, Fe, Al, Zn Cu, Mn As, Ti, V, Cr, Ni, St, Li Ag, Co, Rb, Sn, Mo Ag, U U in bones Ra
Decimal Potency
D1-D2 D2-D3 D3-D4 D4 D5 D5-D6 D6 D11 D1 = 10 to the -1
Weekdays
Sunday
Monday
(French)
Dimanch
Lundi
Planet
Sun
Moon
Tuesday
Thursday Friday Saturday
Mardi
Jeudi Vendredi Samedi
Mars
Mercury Jupiter Venus Saturn
Wednesday Mercredi
Monday's child is fair of face. Tuesday's child is full of grace. Wednesday's child is full of woe. Thursday's child has far to go. Friday's child is loving and giving. Saturday's child works hard for a living, But the child who is born on the Sabbath Day Is bonny and blithe and good and gay.
Weekdays
Sunday
Monday
Child
good and gay
fair of face
Planet
Sun
Moon
Tuesday
Wednesday Thursday Friday Saturday
full of grace
full of woe far to go loving and giving hard for a living
Mars
Mercury Jupiter Venus Saturn
Fortune telling rhymes of this type circulating in England in the 1570s

Electrical Conductivity of Metals

Iodine 8.0E-16 10 6th /cm Sulfur 5.0E-24 10 6th /cm Mercury 0.0104 10 6th /cm Uranium 0.038 10 6th /cm Lead 0.0481 10 6th /cm Tin 0.0917 10 6th /cm Iron 0.0993 10 6th /cm Gold 0.452 10 6th /cm Copper 0.596 10 6th /cm Silver 0.63 10 6th /cm Least
More
Most
Upon this age that never speaks its mind, This furtive age, this age endowed with power To wake the moon with footsteps, fit an oar Into the rowlocks of the wind, and find What swims before his prow, what swirls behind--Upon this gifted age in its dark hour, Rains from the sky a meteoric shower Of facts . . . they lie unquestioned, uncombined. Wisdom enough to leech us of our ill Is daily spun; but there exists no loom To weave it into fabric. . .
"Huntsman, What Quarry?" by Edna St. Vincent Millay
The essence of a living organism lies not in its substance, but in its action. The organization is not a system of substances, it is activity.
Dr. Rudolf Steiner and Ita Wegman, M.D.
Fundamental of Therapy Bradford S. Weeks, M.D. (c) 2009
Lilly Kolisko
http://www.science.a nth.org.uk/kolisko/ http://www.science.a nth.org.uk/kolisko/K olisko_211126.htm http://www.science.a nth.org.uk/kolisko/K olisko_290627.htm
Further Reading 1966 The Nature of Substance - Rudolf Hauschka, trans. from German. 1973 The Secrets of Metals - Wilhelm Pelikan, Anthroposophic Press, trans. from German. 1918 Fundamental of Therapy - Dr. Rudolf Steiner and Ita Wegman, M.D. 1921 Spiritual Science and Medicine - Rudolph Steiner 1537 The Book Concerning the Tincture of the Philosophers - Paracelsus 1531 The Aurora of the Philosophers - Paracelsus Bradford S. Weeks, M.D. (c) 2009
Gold substance Sun forces

Gold for Arthritis

Jacques Forestier (1890 - 1978) was a French internist who was a pioneer in the field of rheumatology. He studied and practiced medicine in Paris, and was founder of the National French Society of Rheumatology. Jacques Forestier is remembered for his introduction of gold salts as a remedy for rheumatoid arthritis. Today, injectable gold salts such as gold sodium thiomalate and aurothioglucose are considered by many to be the most effective treatment for arthritic ailments. (His son, 3rd generation rheumatologist, uses honey bee venom to treat arthritis) Gold isotope 198 is a chemotherapy agent;
Pro-apoptotic effect of aurothiomalate in prostate cancer cells.

Trani M , Sorrentino A , Busch C Landstrm M Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.
It has been recently demonstrated that small gold compounds could have a potential anti-tumoral activity. Here, we report that aurothiomalate (ATM), a gold compound already used in clinical therapy for the treatment of rheumatoid arthritis, has a pro-apoptotic effect in aggressive prostate cancer (PC3U) cells. Moreover we could link ATM treatment to activation of the mitochondrial or so called intrinsic pathway, as we observed release of cytochrome c from mitochondria to cytoplasm, suggesting that the mitochondrial pathway is involved in the pro-apoptotic effect mediated by ATM.
Taken together our data suggest that ATM could be a new promising drug for the treatment of advanced prostate cancer.
Cell Cycle. 2009 Jan 15;8(2):306-13. Epub 2009 Jan 10.
Copper substance Venus forces

- Copper (Cu) shifts attitude between the cuprous (Cu1+) and cupric (Cu2+) forms, (usually cupric in vivo) in order to easily receive and donate electrons in perpetual oxidation-reduction (redox) reactions and also in order to serve as the anti-oxidant function of scavenging free radicals. - Prevents the peroxidation of PUFA maintaining cell membrane integrity. - Maintains myelin sheath via synthesis of phospholipids.
Copper prepares the Bed for Iron

Rudolf Steiner
1) Two copper-containing enzymes, ceruloplasmin (ferroxidase I and II) oxidize ferrous iron (Fe2+) to ferric iron (Fe3+), allowing protein transferrin for transport iron to the site of red blood cell formation. 2) Iron mobilization from storage sites is impaired in copper deficiency
Anemia is a clinical sign not only of iron deficiency but of too little copper also. Ceruloplasmin is required for iron transport to the bone marrow for synthesis of RBC. High levels of dietary zinc increases the synthesis metallothionein, which binds certain metals at the intestinal villi and prevents their absorption. Metallothionein binds copper stronger than zinc, so high levels zinc cause a decrease in the absorption and bioavailability of copper.
Copper-dependent enzyme actions (cuproenzymes)
Cytochrome c oxidase catalyzes the reduction of molecular oxygen (O2) to water (H2O), thereby creating an electrical gradient used by the mitochondria to produce ATP.
Cytochrome c oxidase activity regulates generation and resilience of myelin sheath Lysyl oxidase, is required for the cross-linking of collagen and elastin (support for the integrity of connective tissue in coronary artery system)
Copper-dependent enzyme actions (cuproenzymes) cont.
Dopamine-b-mono-oxygenase catalyzing dopamine -> NE

Monoamine oxidase (MAO) regulate norepinephrine, epinephrine, and dopamine. MAO also functions in the degradation of the neurotransmitter serotonin
Tyrosinase (a cuproenzyme) regulates melanin synthesis

Highest concentration of copper in brain and liver.
Copper deficiency is quite rare in humans.

Copper-dependent enzyme actions (cuproenzymes) cont. Superoxide dismutase (SOD) serves as an antioxidant by catalyzing superoxide radicals to hydrogen peroxide which is easily reduced to water. 1) Intracellular copper/zinc SOD is found within most cells of the body (RBC) 2) extracellular SOD is a copper-containing enzyme (in lungs and plasma). Ceruloplasmin seves as an antioxidant by binding copper, and via its ferroxidase activity facilitates iron joining it transport protein, transferrin, thereby mopping up Fe2+ Copper levels alter the synthesis of gene proteins which regulated by copper-dependent transcription factors (copper/zinc superoxide dismutase (Cu/Zn SOD), catalase (think HDVit C and cancer)S. Weeks, M.D. (c) 2009 Bradford
Mercury substance Mercury forces

Chinese emperor Qin Shi Huang Di buried in tomb with a model of the land he ruled complete with rivers of mercury died from drinking mercury and jade designed to give him eternal life; Ancient Greeks used mercury ointments Romans use mercury cosmetics Indian word for alchemy translates as the way of mercury
Paracelsus
Mercury is harmless in insoluble form (mercuric sulfide) but toxic in mercuric chloride and 2009 methyl/ethyl mercury; Bradford S. Weeks, M.D. (c)
Lewis and Clark expedition: Penis syringe was used to inject mercury solutions directly into the urethra to treat venereal disease symptoms Also used was oral elemental mercury and mercury salves. Paracelsus: first documented use of a metal as medicine, mercury.
Silver substance Moon forces

Palolo Worm
This worm dances to the light of the moon. Spawning follows the lunar cycle, around the seventh night after the full moon that follows the autumnal equinox.
If it's a weak showing, then a second rising can be expected in November.

Clinicial Indications for Silver
- regeneration, - anti-biotic, - tissue detoxification

- see Gary Gordons FACT website: http://promed.gordonresearch.com/factfor um/welcome.html topic silver
IV Silver 250 cc bag colloidal silver 10ppm 3cc of methylcobalamine and 50cc of D50 glucose (to aid absorption) Run at slow drip over 2 hrs NOTE: IV silver for humans is not FDA
approved in USA despite the fact that silver was Americas first IV antibiotic: 1860!
December 20, 2007 the world press published re Paul Karason, a California man whose entire skin gradually turned blue after consuming homemade
colloidal silver containing and silver.
salt, water
(Note: only silver chloride is toxic)

Argyria: blue skin, eyes, nails. Not dangerous, just unsightly

Silicate (with Oxygen) substance Earth forces

Testosterone
Estrogen
Iron substance Mars forces

Oxygen transport and storage: Hemoglobin and myoglobin are heme-containing proteins that store and transport oxygen. Hemoglobin = 2/3 of total body iron Electron transport and energy metabolism: Cytochromes are heme-containing compounds involved in mitochondrial electron transport and ATP production Antioxidant and beneficial pro-oxidant functions: Heme-containing enzymes catalase and peroxidase protect cells against the accumulation of hydrogen peroxide, Oxygen sensing (esp high altitudes or COPD): compensate with RBC formation and angiogenesis
Lead substance Jupiter forces

Lead and Light

Great refraction Great dispersion
Radioactivity Protection against diagnostic radiation Lead has more more naturally occuring isotopes than any other metal
Lead
- Melts by candle flame 327 deg C. - Vaporizes at temperature most metals require to melt 1555 deg C. - Expands and contracts faster and more powerfully than other metals
Just consider where the strongest forces of decomposition are found in the earth, where radium occurs; In lead the cosmos prepares a substance for itself in which to concentrate the most powerful splitting forces. By bringing lead into the human body you place the body directly amid the process of world degeneration; in lead we have an effective means of evoking the forces of decomposition. (Rudolf Steiner)
Uranium and thorium, substances of the highest density are starting points for decomposition into other elements with the accompanying transmutation of matter into radiation, an imponderable, leaving behind finally non-radioactive lead.
Lead as an Anthroposophic remedy (after Rudolf Steiner) Lead mixed with honey and sugar for arteriosclerosis Lead subdues the hypertrophic forces of the astral body that express themselves in craving. It strengthens the forces of the ego organization and produces an antipathy to alcohol. Silver is an antidote to lead.
Lead Toxicity
Neurological Symptoms - Behavioral problems (erratic) - Visual/Auditory dysfunction - Motor deficits (tremor) - Cognitive deficits (dementia, depression),
Osteoporosis Int. 9 (1999)

Lead is a calcium antagonist

- Pb neurotoxicity typically manifests as a disruption of Ca metabolism - Lead keeps Ca channels open about 5X longer than Ca and pollutes cells in that manner.
Mechanism of Lead Neurotoxicity - Activates phosphokinase c (out competes calcium binding creating erratic neuronal responsiveness: impulsivity and restlessness - Inhibits NMDA receptor function - Disrupts synthesis of dopaminergic, cholinergic, and glutamatergic neurotransmitters - Disrupts calcium homeostasis, - Increases erratic and spontaneous NT release - Disrupts microtubule metabolism
Ann Rev Pharmacol Toxicol(1995)35:391
100 Year Old Lead Smelter

Doe Run Co., Missouri
Concentrated Pb ore
Streets: 30-300 K ppm Pb
29% kids BPb 10 g/DL
(Slide from Dr. D. Quig)

Tin substance Saturn forces

Cellular Attributes, Functions & Interactions:
Tin Synergists: Nickel, iodine, Vitamin B1, Vitamin C,

Tin Antagonists / Inhibitors: Iron, calcium, copper, chloride, Vitamin B2, Vitamin E, [bismuth, zinc],
Low Levels / Deficiency - Symptoms and/or Risk Factors:

Fatigue, depression, low cardiac output (left), low adrenals, shortness of breath, asthma, headaches, insomnia. - In animals, low tin results in poor growth, alopecia / bilateral hair loss, hearing loss, and reduced feeding efficiency source http://www.acu-cell.com/tin.html
Tin in the human organism

- Highest in the thymus. - Next in the tongue and salivary mucosa - Then skin - Then liver - Then spleen - Then brain - Then heart
Tin concentration in the thymus glands of rats and mice and its relation to the involution of the gland.
Sherman LR, Masters J, Peterson R, Levine S
Tin is an ubiquitous element and thus enters mammals through the food chain. It has never been found to be dysfunctional in either plants or animal tissue and has been regarded as an innocuous background material. Of the many organs and glands that have been analyzed for tin,
only the thymus gland exhibits an above average value
The tin analysis of the muscle, spleen, and thymus indicated constant values for the muscle and spleen tissue, but an increase in the thymic tin concentration (ppm) with age. The increase indicates that the tin was probably located in the medulla of the thymus, which may be the active biochemical site for tin in rodents. J Anal Toxicol 1986 Jan-Feb;10(1):6-9
The neurotoxicology and pathology of organomercury, organolead, and organotin. Chang LW

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205.
Organotin compounds have been used in plastic industries and as agricultural chemicals. Both trimethyl and triethyl tin compounds are found to be extremely neurotoxic. Despite the similarity of their chemical structures, trimethyl and triethyl tins have a diversely different toxic property and effects. While triethyl tin is myelinotoxic, producing edematous and vacuolar changes in the central myelin, trimethyl tin is neurotoxic, producing prominent toxic changes in the neurons of the limbic system (hippocampus, entorhinal cortex, etc.). The factors which determine the specificity and selectivity of the neurotoxic impacts by various organometals are still unknown.
J Toxicol Sci 1990 Dec;15 Suppl 4:125-51
Tin as a Remedy
to bring form to a disordered structure RS regulates opposing fields of force RS - Hydrocephalus - Tuberculosis and Pleurisy - Liver congestion - Eczema - Joint effusions - the tin cry when it is bent - Immune function
Tin and the thymus gland: a review.

Cardarelli N
Engineering and Science Technology U of Akron, OH 44325.
Experimental studies over the last decade have suggested an association between thymus immune and homeostatic function and exogenous tin. It has been hypothesized that the thymus gland synthesizes and secretes one or more tin bearing factors that enhance immune defenses against malignancy and retard the gradual loss of immune capacity with senescence.
Thymus 1990 Jun;15(4):223-31

Tin Sources: Tinned / canned foods, cereal grains, dairy, meat, vegetables, seaweed, licorice, some toothpastes
Paracelsus Oath: This is my Vow: To perfect my medical art and never to swerve from it so long as God grants me my office, and to oppose all false medicines and teachings. Then to love the sick, each and all of them, more than if my own body were at stake. Not to judge superficially, but by symptoms, nor to administer any medicine without understanding, nor to collect any money without earning it. Not to trust any apothecary, nor to do any violence to any child. Not to guess, but to know. Paracelsus 1493 - 1541
Other Elements (non-planetary) relevant to health
Calcium
99% of our Calcium ~ 1 kg ~ is in bones
- Osteoporosis is initially a magnesium disorder -> disrupted calcium deposition (magnesium hardens teeth, not calcium)
- Take Cal and Mag @ 1:1 c D3 5000u/day some say to not take together: antagonists - See www.notmilk.com
Zinc
- Clinical zinc deficiency humans first described in 1961, "adolescent nutritional dwarfism" Middle East - Zinc regulates growth and development, buttresses the immune response, supports neurological function, and reproduction. - > 100 different catalytic enzymes depend on zinc - Zinc supports protein and cell membrane structure - Zinc regulates gene expression functioning as transcription factors as they bind to DNA - Zinc is instrumental in cell signaling esp. re hormone release and nerve impulse transmission and apoptosis
Clinical Indications
- Skin - Immune function - Nerve sense - Eyes - Hearing - Regeneration of tissues
New From Dr. Kunin
The worlds best deodorant~ think zinc! Bradford S. Weeks, M.D. (c) 2009
Magnesium
Light bearer Ignite a disc the size of sun hold up to the sun and magnesium burns as brightly Stepping stone for light to become sugar Where the imponderable gathers substance Respiration for plants chlorophyll
Magnesium: Clinical Indications

Rhymes with spasm (use it thusly)
Constipation Twitching (Chovsteks sign) Headache Fibromyalgia Uterine cramps Pre-chiropractic visit Preeclampsia Alcoholism Angina Insomnia (relax muscles) Claudication Anxiety (soma & psyche) Mitral Valve GERD, gastritis Prolapse Dental health (enamel) Seizure High Cholesterol Prevention Diabetes (metabolizes glucose) Bradford S. Weeks, M.D. (c) 2009
Iodine/Iodide Clinical Indications

Russian wisdom: If the problem is internal, drink iodine, If the problem is external, paint iodine.
Thyroid disorders Cancer (enhances apoptosis) ASCVD Immune function Cystic processes -Fibroids (labial swab with Lugols) -Fibrocystic breast Bradford S. Weeks, M.D. (c) 2009 disease
Iodine Deficiency
- Most commonly preventable cause of mental retardation - Most common cause of endocrinopathy (goiter and primary hypothyroidism). - Neurological damage during fetal development as well as during lactation. - The safety of therapeutic doses of iodine above the established safe upper limit of 1 mg is evident in the lack of toxicity in the Japanese population that consumes 25 times the median intake of iodine consumption in the United States. (Japan's population suffers no demonstrable increased incidence of autoimmune thyroiditis or hypothyroidism) - Klein-Levy Syndrome - myxedema coma (case report)
Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine.
Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ. Department of Surgery, Drexel University College of Medicine, Philadelphia, PA The protective effects of iodine on breast cancer have been postulated from epidemiologic evidence . suggests that iodine may inhibit cancer promotion through modulation of the estrogen pathway. Quantitative RT-PCR confirmed the array data demonstrating that iodine/iodide treatment increased the mRNA levels of several genes involved in estrogen metabolism (CYP1A1, CYP1B1, and AKR1C1) while decreasing the levels of the estrogen responsive genes TFF1 and WISP2. This report presents the results of the first gene array profiling of the response of a breast cancer cell line to iodine treatment. In addition to elucidating our understanding of the effects of iodine/iodide on breast cancer, this work suggests that iodine/iodide may be useful as an adjuvant therapy in the pharmacologic manipulation of the estrogen pathway in women with breast cancer. Int J MedBradford S. Weeks,8;5(4):189-96. Sci. 2008 Jul M.D. (c) 2009
Iodine and Breast Cancer

Iodine: deficiency and therapeutic considerations.
Patrick L. Southwest College of Naturopathic Medicine, USA. lpatrick@frontier.net
Studies using 3.0- to 6.0-mg doses to effectively treat fibrocystic breast disease may reveal an important role for iodine in maintaining normal breast tissue architecture and function. Iodine may also have important antioxidant functions in breast tissue and other tissues that concentrate iodine via the sodium iodide symporter.
Altern Med Rev. 2008 Jun;13(2):116-27
Find a cure before I grow boobs!

David Derry, M.D.
&
David Brownstein, M.D.
Tin (Sn) is associated with Iodine (I) the same way as calcium is associated with magnesium. Tin supports the adrenals, iodine supports the thyroid, both then affect cardiac output: Tin + adrenals control the left side, Iodine + thyroid control the right side. http://www.acu-cell.com/sni.html
Food Serving Salt (iodized) 1 gram Cod 3 ounces* Shrimp 3 ounces Fish sticks 2 fish sticks Tuna, canned in oil 3 ounces (1/2 can) Milk (cow's) 1 cup (8 fluid oz) Egg, boiled 1 large Navy beans, 1/2 cup Potato w peel 1 medium Turkey breast, 3 ounces Seaweed1/4 oz Variable;
Iodine (mcg) 77 99 35 35 17 56 12 32 60 34 4,500 mcg
A three-ounce serving of meat is about the size of a deck of cards. Turkey and potato were baked, navy beans cooked
Only Mae West believes Too much of a good thing is wonderful! Be careful with excess iodine.
Association of High Iodine Intake with the T1799A BRAF Mutation in Papillary Thyroid Cancer.
Guan H, Ji M, Bao R, Yu H, Wang Y, Hou P, Zhang Y, Shan Z, Teng W, Xing M.
J Clin EndocrinolM.D. (c) 2009 2009 Feb 3 Bradford S. Weeks, Metab.
Iodine Drug interactions
Amiodarone contains high levels of iodine and may affect thyroid function.
Lithium in combination with SSKI -> hypothyroidism. SSKI -> less anticoagulant effect of warfarin
Acute Iodine Toxicity

This is rare (requires gram dosing) Symptoms: burning of the mouth, throat, and stomach; fever; nausea; vomiting;Bradford S. Weeks, a weak pulse; and coma diarrhea; M.D. (c) 2009
Selenium
glutathione peroxidase (anti-oxidant) cytochrome P450 detoxification of xenobiotics;
Clinical indications: cancer viral infection infertility heavy metal detoxification macular degeneration
Selenium
Birth control for virus / viri
E.W. Taylors theory that viruses encode for the selenoenzyme glutathione peroxidase because they have a practically identical enzyme - the net result being selenium deficiency for humans and subsequent immunocompromised status.
See Selenium and cellular immunity. Evidence that selenoproteins may be encoded in the +1 reading frame overlapping the human CD4, CD8, and HLA-DR genes. Taylor EW. Biol Trace Elem Res. 1995 Aug-Sep;49(23):85-95. Functional studies of an HIV-1 encoded glutathione peroxidase Zhao L, Olubajo B, Taylor EW Biofactors. 2006;27(1-4):93-107 http://www.hdfoster.com/WhatReallyCausesAIDS.pdf By Harold Foster Bradford S. Weeks, M.D. (c) 2009
Lithium for Learning

Lithium: The Misunderstood Mineral Part 1 By Jonathan V. Wright, M.D. (Reprinted From "Nutrition and Healing")
Think young into your 90s with this anti-aging secret for your brain
Chronic lithium treatment magnifies learning in rats.

Nocjar C, Hammonds MD, Shim SS. Dept Psychiatry, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44141, USA. cxn18@cwru.edu
Recent electrophysiological work shows that chronic lithium treatment increases long-term potentiation (LTP) in neurons of the hippocampus, and LTP is thought to be the major neurophysiological basis for the development of learning and memory. This suggests that lithium might enhance learning and memory. Thus chronic lithium treatment may improve learning and memory in Alzheimer's disease, and do so not only by blocking the formation of beta-amyloid and neurofibrillary tangles as suggested by previous research, but also by enhancing mechanisms involved in basal learning and memory formation, such as hippocampal synaptic plasticity.
Neuroscience. 2007 Dec 19;150(4):774-88.
Lithium and cognitive enhancement: leave it or take it?

Tsaltas E, Kontis D, Boulougouris V, Papadimitriou GN. Experimental Psychology Laboratory, Department of Psychiatry, Eginition Hospital, Athens, Greece, tsaltasl@med.uoa.gr. Lithium is established as an effective treatment of acute mania, bipolar and unipolar depression and as prophylaxis against bipolar disorder. Accumulating
evidence is also delineating a neuroprotective and neurotrophic role for lithium.

Psychopharmacology 2009 Jan;202(1-3):457-76.
N-methyl-D-aspartate receptors are involved in lithium-induced state-dependent learning in mice. Rezayat M, Niasari H, Ahmadi S, Parsaei L, Zarrindast M. Department of Pharmacology, School of Medicine, Tehran, Iran.
We have previously shown lithium-induced statedependent learning in a step-down inhibitory avoidance task. The results suggest that NMDA receptors may be involved, at least partly, in the lithium-induced statedependent learning.
J Psychopharmacol. 2009 Jan 22. [Epub ahead of print]
Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils.
Bian Q, Shi T, Chuang DM, Qian Y.
Dept Anesthesiology, Nanjing Medical U, Nanjing, PR China.
This is believed to be the first report of lithium-induced protection against hyperactivity in a novel open field and memory impairment in a gerbil model of global ischemia. These results underscore the ability of lithium to improve functional behavioral outcome in gerbil and rodent cerebral ischemic models and further indicate the potential therapeutic use of lithium in certain human stroke conditions. Brain Res. 2007 Dec 12;1184:270-6
Cobalt
Rx Vitamin B IM shots
Start with Folic Acid cc (precipitates) then draw up Vitamin B12 ( or methylcobalamine) 1 cc then draw up Vitamin B complex 1 cc, and lastly Vitamin B6 (pyridoxine HCL) cc (= 3 cc total) Take one shot as instructed with sterile procedure in upper outer buttock (alternate sides) aim CHEEK to CHEEK. Do this every AM for 30 days then we will reassess to determine any changes in dosage and frequency. Dispense: #4 vials, #30 3 cc syringes, 30 gauge needles, betadine Can substitute Folic acid with ACE 0.5 cc or Procaine 0.5 cc or Glutathione 0.5 cc or Liver Extract 0.5 cc
Methylcobalamin used in peripheral neuropathy, diabetic neuropathy and disruptions of sleep-wake rhythms. Cobalamins with folic acid enable DNA synthesis in cells (in bone marrow and myeloid cells) and are essential cofactors for two cellular reactions:
(1) the mitochondrial methylmalonyl coenzyme A mutase conversion of methylmalonic acid (MMA) to succinate, which links lipid and carbohydrate metabolism, and (2) activation of methionine synthase, which is the rate limiting step in the synthesis of methionine from homocysteine and tetrahydrofolate
Chromium
- metabolism of cholesterol and glucose; - assists with ASCVD, hypoglycemia, diabetes, - GTF (niacin, glycine glutamic acid, cysteine, and trivalent chromium) - hexavalent chromium is very toxic
Manganese
Manganese is an essential mineral element that is potentially toxic. The derivation of its name from the Greek word for magic magikos remains appropriate because it plays an important role in transmutation as a constituent and an activator of many enzymes.
Food Pineapple, raw

Pineapple juice Pecans Almonds Peanuts
Serving 1/2 cup, diced 1/2 cup (4 ounces) 1 ounce 1 ounce 1 ounce
1 packet 1 cup
Mn 0.91g
0.63 1.28 0.72 0.55 1.68 1.88
Instant oatmeal (prepared with water) Raisin bran cereal Brown rice, cooked Whole wheat bread
1/2 cup 1 slice
0.88 0.60
In mg
Manganese-activated enzymes - critical in metabolism COH, bone, amino acids Example of manganese containing enzymes:
1) Pyruvate carboxylase - gluconeogenesis 2) Phosphoenolpyruvate carboxykinase - gluconeogenesis 3) Arginase required by the liver for the urea cycle (helps detoxifies ammonia) 4) Glycosyltransferases - synthesis of proteoglycans (bone and cartilage) 5) Prolidase, prepares proline, for collagen formation 6) Glycosaminoglycan synthesis (manganese-activated glycosyltranserases) wound healing
Manganese and Wound Healing

Shetlar MR, Shetlar CL. The role of manganese in wound healing. In: KlimisTavantzis DL, ed. Manganese in health and disease. Boca Raton: CRC Press, Inc.; 1994:145-157.
Manganese superoxide dismutase (MnSOD) is the principal antioxidant enzyme in the mitochondria. MnSOD catalyzes the conversion of superoxide radicals to hydrogen peroxide, (itself reduced to water)
Manganese Deficiency - impaired glucose tolerance - increased diabetes - altered carbohydrate metabolism - altered lipid metabolism - bone demineralization and impaired growth (note: blood calcium, phosphorus, and alkaline phosphatase levels were also elevated suggesting increased bone remodeling women with OP have lower serum MN levels - decreased serum cholesterol levels - transient skin rash - lowered seizure threshold
Manganese - Clinical indications

- diabetes - asthma - fatigue - allergies - osteoarthritis - tendonitis - manages metabolism of COH, proteins and fats - vital to thiamine metabolism, vitamin E utilization and mucopolysacharide formation
Manganism Mn Toxicity: ~Parkinsons

- Phase I Psychiatric Abnormalities: Hyperirritability, violence, compulsiveness, forced laughter, apathy, sleep disturbance - Phase II Neurological Disorder of Extrapyramidal Motor System: Tremor, loss of speech/motion coherence, high-stepping gait (velcro feet), mask-like face - Phase III Bradykinesia, rigidity Slide from D. Quig, DD Ref. Environ Health Perspective (2000)108;429-32 Bradford S. Weeks, M.D. (c) 2009
Carl GF, Gallagher BB. Manganese and epilepsy.
In: Klimis-Tavantzis DL, ed. Manganese in health and disease. Boca Raton: CRC Press, Inc; 1994:133-157.
discovery of manganese as a cure for drug-induced dyskinesia was the first orthomolecular research to verify the efficacy of mineral therapy for a disease (other than simple deficiency).
http://orthomolecular.org/hof/2008/kunin.html
Sir Richard Kunin

Orthomolecular Hall of Fame Founder & Leader OMS Closet Alchemist Walker of the Talk NOTE: he hasnt aged a bit
Title Page: Joseph ben Abraham Gikatilla, Portae lucis, 1516.
SUMMARY and RECOMMENDATIONS
Mineral Digestion A Chelation Process

Foods
Minerals as protein complexes
Unless bone is consumed to get hydroxyapatite salts Stomach Acid causes neutralization of carboxylic acids Minerals become free ions with chloride and phosphate as counter-ions Duodenum Alkaline pancreatic juice neutralizes chyme Carboxylic acids take on negative charge again New chelates and complexes form Small intestine Selective uptake of ionic forms under tight control of regulatory proteins
Your best mineral supplement?

1) Avoid milk (antacid) 2) Betaine HCL and pepsin with each meal layer it in with food
Betaine HCL (COH, protein, fats) + Pepsin (splits proteins)
Dropping Acid
Bradford S. Weeks, M.D. (c) 2009 see http://weeksmd.com/?p=96
ee cummings "Oh, sweet spontaneous earth, how often have the doting fingers of prurient philosophers pinched and poked thee, has the naughty thumb of Science prodded thy beauty. How often have Religions taken thee upon their scraggy knees squeezing and buffeting thee that thou mightest conceive Gods (but true to the incomparable couch of death, thy rhythmic lover, thou answerest them only with spring)"
Welcome to Come and BradfordUs in M.D. (c) 2009 Visit S. Weeks, Seattle!

A Perspective On Minerals and Metals in Human Health

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A Perspective on Minerals & Metals in Human Health

Bradford S. Weeks, M.D. www.weeksmd.com md@weeksmd.com

Bradford S. Weeks, M.D. (c) 2009

Lithium #3 in the periodic table = 3 protons

Bradford S. Weeks, M.D. (c) 2009

Element Lithium Beryllium Boron Carbon Nitrogen Oxygen Fluoride

Bradford S. Weeks, M.D. (c) 2009

Element Hydrogen Lithium Sodium Potassium Rubidium Cesium

Egyptian signs for the Elements

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

Which box are you thinking outside of?

Knowing and Thinking

Engraving from Baro Urbigerus Besondere chymische Schrifften, 1705.

Frontispiece engraving from 1774 Drey curieuse chymische tracttlein

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

paraphrase Rudolf Steiner Occult Science

Metallic Presence in Humans

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

Fortune telling rhymes of this type circulating in England in the 1570s

Electrical Conductivity of Metals

Bradford S. Weeks, M.D. (c) 2009

Fundamental of Therapy Bradford S. Weeks, M.D. (c) 2009

Gold substance Sun forces

Gold for Arthritis

Pro-apoptotic effect of aurothiomalate in prostate cancer cells.

Copper substance Venus forces

Copper prepares the Bed for Iron

Copper-dependent enzyme actions (cuproenzymes)

Copper-dependent enzyme actions (cuproenzymes) cont.

Dopamine-b-mono-oxygenase catalyzing dopamine -> NE

Tyrosinase (a cuproenzyme) regulates melanin synthesis

Copper deficiency is quite rare in humans.

Mercury substance Mercury forces

Silver substance Moon forces

If it's a weak showing, then a second rising can be expected in November.

Bradford S. Weeks, M.D. (c) 2009

Clinicial Indications for Silver

- regeneration, - anti-biotic, - tissue detoxification

colloidal silver containing and silver.

(Note: only silver chloride is toxic)

Argyria: blue skin, eyes, nails. Not dangerous, just unsightly

Silicate (with Oxygen) substance Earth forces

Bradford S. Weeks, M.D. (c) 2009

Iron substance Mars forces

Lead substance Jupiter forces

Lead and Light

Bradford S. Weeks, M.D. (c) 2009

Bradford S. Weeks, M.D. (c) 2009

Osteoporosis Int. 9 (1999)

Lead is a calcium antagonist

Bradford S. Weeks, M.D. (c) 2009

100 Year Old Lead Smelter

29% kids BPb 10 g/DL

(Slide from Dr. D. Quig)

Tin substance Saturn forces

Cellular Attributes, Functions & Interactions:

Tin Synergists: Nickel, iodine, Vitamin B1, Vitamin C,

Low Levels / Deficiency - Symptoms and/or Risk Factors: