th 4

International Conference for IPT Practitioners

Innovations in Cancer Care Chicago 2008

Topical and Systemic Treatments of

(people with)

Skin Cancer
Bradford S. Weeks, M.D. Corrective Medicine and Psychiatry
360-341-230 www.weeksmd.com

"When an animal dies, it leaves behind his skin.

When a man dies, all he leaves behind is his reputation."

Korean Proverb

Which box are you thinking outside of?

"A physician once told me that nothing arouses so much bitter enmity and heated arguments among his colleagues, as the subject of cancer. This may be due to the guilty recollections of cancer victims expiring who might have been saved; or of the memories of patients pronounced hopelessly ill who recovered under the treatment of a 'quack,' or who miraculously lived without further treatment. Possibly these guilt reactions and the remorse over exhausting the money of patients and their relatives in futile cancer treatments, account for some of these psychological manifestations which are expressed in hostility and attack."

Nat Morris (written in 1958)

Even Bill Gates took some risks in life

"The universities do not teach all things ... so a doctor must seek out old wives, gypsies, sorcerers, wandering tribes, old robbers, and such outlaws and take lessons from them. A doctor must be a traveller. Knowledge is experience." Paracelsus (1493-1541)

Brief Pictorial Review of Human Skin Cancers

Actinic keratoses may itch or burn.

Squamous cell cancer effects men more than women

Bowens is the earliest form of squamous cell cancer

Basal Cell Cancer

Melanomas occur anywhere on body

"ABCDE" A stands for Asymmetry, B stands for Border, C for Color, D for Diameter E for Evolving ~ 4 types of melanoma 3 in situ 1 invasive at start

Antioxidant supplementation and risk of incident melanomas: results of a large prospective cohort study. Asgari MM
OBJECTIVE: To examine whether antioxidant supplement use is associated with melanoma risk in light of recently published data from the Supplementation in Vitamins and Mineral Antioxidants (SUVIMAX) study, which reported a 4-fold higher melanoma risk in women randomized to receive a supplement with nutritionally appropriate doses of antioxidants.

Conclusion: Antioxidants taken in nutritional doses do not seem to increase melanoma risk.
Arch Dermatol. 2009 Aug;145(8):879-82.

Centers for Disease Control and Prevention. Sunburn Prevalence Among Adults United States, 1999, 2003, and 2004. Morbidity and Mortality Weekly Report 2007; 56(21):524-528.

Blacks are more than three times as likely as whites to be diagnosed with melanoma after it has reached a late stage, and Hispanics are nearly twice as likely, according to a University of Miami study released Monday.
http://www.msnbc.msn.com/id/13441328

Bob Marley malignant melanoma RIP

Non-sunscreen photoprotection: antioxidants add value to a sunscreen. Matsui MS, et al

Non-sunscreen protective strategies have been developed. These include topically applied botanical extracts and other antioxidants as well as topical DNA repair enzymes. Standard terms of photoprotection such as sun protection factor (SPF) do not accurately reflect the photoprotection benefits of these materials. J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.

Tea extract containing polyphenols via ability to reduce oxidative stress and inhibit NF-kB. Botanical antioxidants and vitamins C and E to a broadspectrum sunscreen may further decrease UV-induced damage compared with sunscreen alone. Conclusion: Non-sunscreen materials such as botanical extracts, antioxidants, and DNA repair enzymes can contribute value when applied topically to human skin in vivo. J Investig Dermatol Symp Proc. 2009 Aug;14(1):56-9.

Cancer is not the problem.

Cancer is an adaptive response to the problem.

Toxic blood and tissue is the Problem

Every town has a garbage dump. Solution: make less trash, recycle. To avoid cancer: eat non-toxic foods and eat less!

Removing the tumor is the least important step in curing cancer.

Whidbey Island mushroom - Cancer Metaphor

Basal, squamous cell carcinomas and melanomas and their precancerous keratotic cousins represent better than 50% of the average dermatologists work.

Insulin Potentiation Therapy

Hard on the cancer, Easy on the patient.

Threefold approach to treating

(people with)

skin cancer
1) get rid of the tumor (least important) 2) take down the cancer welcome sign 3) enhance immune vitality

Oxygen breathing may be a cheaper and safer alternative to exogenous erythropoietin (EPO)
Recently discovered normobaric oxygen paradox demonstrates that renal tissue can be stimulated to increase EPO production via a simple pattern of oxygen breathing at normal atmospheric pressures. This leads directly to the hypothesis that oxygen breathing may provide chemotherapy patients with a convenient and inexpensive alternative to ESAs. Stimulating endogenous EPO production eliminates the small risk of immune system reaction associated with ESAs. Further, the endogenous physiological EPO doses provided by this method may be safer, in terms of cancer mortality, than the exogenous pharmacological doses inherent in ESA administration. Author: R. Burk Medical Hypothesis published on line 5/ 11/ 07

Change Diet Change Lifestyle Change Level of Enjoyment Change Beliefs and Attitude.
The Challenge: People want to be cured with their sins, not from their sins.

SUN WORSHIP

Mom smearing sunscreen

to avoid.Sunburn

Does sun exposure increase the risk of skin cancer?

Poison is a matter of dosage. Toxicity depends on degree of insult (dose/time) and degree of resistance (nutrient status, immune enthusiasm)

UVA vs. UVB sunscreens vs. tanning salons Goethes dying words: Mehr Licht!

Systemic Interventions

The Four Bodies The Violin Concert

Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin.

Afaq F, et al
Solar ultraviolet (UV) radiation, particularly its UVB (290-320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. UVB radiation causes DNA damage, protein oxidation and induces matrix metalloproteinases

Pomegranate, from the tree Punica granatum, contains anthocyanins and hydrolysable tannins and possesses strong antioxidant and anti-tumorpromoting properties. Conclusion: pomegranate-derived products may be useful against UVB-induced damage to human skin.
Exp Dermatol. 2009 Jun;18(6):553-61. Epub 2009 Mar 6.

5-Methyltetrahydrofolate can be photodegraded by endogenous photosensitizers. Free Radic Biol Med. 2009 Oct 15;47(8):1199-204. Epub 2009 Aug 6.

Beta-carotene prevents ozoneinduced proinflammatory markers in murine skin. Toxicol Ind Health. 2009 MayJun;25(4-5):241-7.

Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UVabsorbing compounds. (the red alga Porphyra rosengurttii) De la Coba, F. J Dermatol Sci. 2009 Sep;55(3):161-9. Epub 2009 Jul 7.

Chemoprevention of human actinic keratoses by topical DL-alpha-tocopherol. Foote JA et al Prior research shows that topical application of free, nonfatty acid-conjugated vitamin E (DL-alphatocopherol) prevents skin cancer in mice, as well as immunosuppression induced by UVB radiation. This study investigated the chemopreventive potential of DL-alpha-tocopherol in humans through monitoring surrogate end point biomarkers in sundamaged skin.

Conclusion: DL-alpha-tocopherol-induced reductions in polyamine metabolism are consistent with the inhibition of skin squamous cell carcinogenesis as seen in previous human trials and animal models.

Cancer Prev Res (Phila Pa). 2009 Apr;2(4):394-400. Epub 2009 Mar 31.

A preponderance of evidence from the best observational studies... has led to the conclusion that public health action is needed. Primary prevention of these cancers has been largely neglected, but we now have proof that the incidence of colon, breast and ovarian cancer can be reduced dramatically by increasing the public's intake of vitamin D."
Professor Cedric Garland the University of San Diego, California after reviewing 63 recent studies on vitamin D and cancer.

A daily dose of vitamin D3 could cut the risk of cancers of the breast, colon and ovary by up to a half, a 40-year review of research has found. The evidence for the protective effect of the "sunshine vitamin" is so overwhelming that urgent action must be taken by public health authorities to boost blood levels, say cancer specialists.

Topical Interventions

Cancerlytic Herbsa history of suppression

http://www.altcancer.com/lysis.htm http://www.meditopia.org/index_ing.htm

Escharotic agents, Fred Mohs, and Harry Hoxsey JD. Elston J. American
Academy of Dermatology, Vol 53, I 3, P 522-524

Topical Agents
iodine (Lugols / SSKI) vitamin A, E, C selenium zinc cesium enzymes raw honey all can be potentiated with DMSO

Escharotics (caustic compounds) - botanical ingredients - metal salt, often a halogen metal (halide), - potassium iodine -"butter of antimony" (antimony trichloride) Many dermatologists are aware that along with zinc chloride, butter of antimony was one of the ingredients in a number of early escharotics of the 1900's. But its use goes back even to Paracelsus in the 1500's --

Curcumin, the yellow pigment found in the spice turmeric and a key ingredient in yellow curry inhibits melanoma cell growth and stimulates tumor cell death via apoptosis potent antioxidant, anti-inflammatory and cancer terminating effects

CANCER August 15, 2005

Zinc chloride was one of just three ingredients in the initial Mohs surgical paste that is now central to a standard dermatological procedure approved through the West. The three ingredients that Mohs used in his formula and taught were: zinc chloride, bloodroot, and stibnite (antimony sulfide, another Paracelsus favorite)

Standard of Care: Mohs micrographic surgery is the best procedure to preserve skin tissue surrounding the cancer. But it requires special training and equipment, and it is timeconsuming and expensive.

Harry S. Hoxsey's formula was almost identical to Mohs. The difference? Mohs called the topical a "fixative," and he artificially and unnecessarily inserted the act of surgery as a necessary part of the process. Yet the AMA, FDA and other pillars of orthodox medicine exerted enormous effort to put Harry S. Hoxsey out of business

Zinc chloride has no capacity to discriminate healthy from malignant tissues. the healthy tissue is definitely not impervious to this product. "Zinc chloride is made by pouring hydrochloric acid over zinc. It is extremely caustic and may damage skin." www.cancersalves.com/ Ingrid Naimen

Dr. Jonathan Hartwell, one of the founders of the National Cancer Institute, spent most of his adult life categorizing cancer herbs and eschoterotics, leaving behind a reference that would become a classic in the field of phytopharmacology and ethnobotany.
Jonathan L. Hartwell, Plants Used Against Cancer, Quarterman Publications, Inc., Lawrence, Mass., 1982. (Out of print).

Bloodroot ointment was made and used by Indians of the Lake Superior region to treat cancer, even uterine.

Sanguinaria canadensis

The Doctrine of Signatures (bloodroot)

THE LEG

THE SHOULDER

THE CHEST

THE CHEEK

THE BACK

Temporary fever from a hot shower

Hypotheramia Hypoglycemia

HOMEOSTASIS
Hypertheramia
Hyperglycemia

Give me the power to create a fever and I will cure all illnesses.
Parmenides (540-480 b.c.)

Topical, localized Fever duration ~ 24 hours

Anti-Cancer effects of
topical honeybee venom (BVT)

Expression of COX-2 mRNA and synthesis of PGE(2) were inhibited by Bee Venom. These results suggest the possibility that Bee Venom may exert an anti-tumor effect on human lung cancer.

Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299.
J Pharmacol Sci. 2003 Feb;91(2):95-104. Jang MH,

Bee venom induces apoptosis and inhibits expression of cyclooxygenase2 mRNA in human lung cancer cell line NCI-H1299. J Pharmacol Sci. 2003 Feb;91(2):95104. Jang MH, Shin MC, Seoul, Korea.

Cytotoxic properties of immunoconjugates containing melittin-like peptide 101 against prostate cancer: in vitro and in vivo studies.
Russell PJ, Hewish D, Carter T et al.

The induced apoptosis of recombinant adenovirus carrying melittin gene for hepatocellular carcinoma cell.
[Article in Chinese] Li B, Ling CQ, Zhang C Li SX

Inhibitory effect of recombinant adenovirus carrying melittin gene on hepatocellular carcinoma.

.

Ling CQ, Li B, Zhang C

Ann Oncol. 2005 Jan;16(1):109-15

[Effect of melittin on apoptosis and necrosis of Osteosarcoma cells]

Chen YQ, Zhu ZA, Zhang C

CONCLUSION: Melittin inhibits the

proliferation of osterosarcoma cell line through up-regulating Fas expression and inducing apoptsis.

Dear Dr. Weeks, In our studies we successfully destroyed prostate and breast cancer tumors and metastases with membrane disrupting peptides; examples for these are naturally occurring peptides like mellitin.

These peptides destroy the outer cell membrane and cause rapid cell death in vitro and in vivo.
Carola Leuschner, PhD

Anti Skin Cancer effects of

topical honeybee venom (BVT)

Effect of honey bee venom on proliferation of K1735M2 mouse melanoma cells in-vitro and growth of murine B16 melanomas in-vivo. J Pharm Pharmacol. 2002 Aug;54(8):1083-9. Liu X, China.

Bee venom has been reported to exhibit antitumour activity in-vitro and in-vivo.
Apoptosis, necrosis and lysis of tumour cells were suggested as possible mechanisms by which bee venom inhibited tumour growth.

The in-vivo experiment indicated that bee venom could be used as a chemotherapeutic agent against malignant tumors.

A matrix metalloproteinase 2 cleavable melittin/avidin conjugate specifically targets tumor cells in vitro and in vivo.

Int J Oncol. 2003 Jan;22(1):93-8. Holle L, Song W,

Melittin alone is extremely toxic to cells and induces immediate cell lysis, but becomes inactive when coupled with avidin. The incorporation of the MMP2 target sequence into the peptide was used as a means for targeting tumor cells.

Hyaluronan promotes tumorigenesis, the level of HA on the surface of cancer cells correlating with aggressiveness and poor outcome.
(Zhang et al., 1995)..

Consideration of Risks and Benefits One of the Arts of Medicine

SUMMARY: The Standard of Care is sub-therapeutic.

"I die by the help of too many physicians."

Alexander the Great
on his deathbed, 323 B.C.

SUMMARY (cont.):

Non-standard of Care treatment modalities both Topical and Systemic exist and are well supported by scientific literature as well as clinical practice.

"Caustics should be tried before knife or cautery."

Aulus Cornelius Celsus, the first century
Roman physician and medical writer in his book "De medicina," 1478

The Role of Hope

and

The Role of Having a Reason to Live

Why we offer beyond the standard of care therapies?

1) more effective treatment 2) more grateful patients 3) more personal and professional satisfaction

Dear Dr. Weeks, After my amazing treatments at your wonderful clinic, I feel so fantastic that I think I can walk on water. But I know that you can!

We all can walk on water. It is only a matter of motivation.

WELCOME TO VISIT US IN SEATTLE !

THE END

I thank my esteemed friends and colleagues for your kind attention and invite any questions.