Inheritance Patterns

Gregor Mendel
 Documented a mechanism of
inheritance through his experiments
with garden peas
 Mendel discovered
 A ratio of about three to one, purple to white
flowers, in the F2 generation

EXPERIMENT True-breeding purple-flowered pea plants and

white-flowered pea plants were crossed (symbolized by ×). The
resulting F1 hybrids were allowed to self-pollinate or were cross-
pollinated with other F1 hybrids. Flower color was then observed
in the F2 generation.

RESULTS Both purple-flowered plants and white-

flowered plants appeared in the F2 generation. In Mendel’s
experiment, 705 plants had purple flowers, and 224 had white
flowers, a ratio of about 3 purple : 1 white.
 Practice Punnett Squares
Ratio –

Proportion –

Ratio –

Proportion –
18.2/18.4
Mendel observed the same
pattern
 In many
other pea
plant
characters
 Mendel’s Hypothesis
 First, alternative versions of genes
 Account for variationsAlleleinfor purple
inherited
flowers

characters, which are now called

alleles

Homologous
Locus for flower-color gene pair of
chromosomes

18.1
Allele for white flowers
 Mendel’s Hypothesis

 Second, for each character

 An organism inherits two alleles, one
from each parent
 A genetic locus is actually represented
twice

18.1
 Mendel’s Hypothesis

 Third, if the two alleles at a locus

differ
 Then one, the dominant allele,
determines the organism’s
appearance
 The other allele, the recessive allele,
has no noticeable effect on the
organism’s appearance
18.1/ 18.5
 Mendel’s Hypothesis

 Fourth, the law of segregation

 The two alleles for a heritable
character separate (segregate) during
gamete formation and end up in
different gametes

18.1
 More Genetic Vocabulary
 An organism that is homozygous for a
particular gene
 Has a pair of identical alleles for that gene
 True-breeding
 An organism that is heterozygous for a
particular gene
 Has a pair of alleles that are different for that
gene

18.5
  An organism’s  An organism’s
phenotype genotype
 Is its physical  Is its genetic
appearance makeup

18.5
 A Testcross
 Allows us to determine
the genotype of an
organism with the
dominant phenotype,
but unknown genotype
 Crosses an individual
with the dominant
phenotype with an
individual that is
homozygous recessive
for a trait

18.6
 The Dihybrid Cross

 Illustrates the inheritance of two

characters
 Helped Mendel develop the law of
independent assortment
 Each pair of alleles segregates
independently during gamete formation

18.3
Dihybrid Cross

18.3
 PRACTICE

Genotypic ratio –

Phenotypic ratio –

18.3
Unfortunately…
 Inheritance
patterns are
often more complex than
predicted by simple
Mendelian genetics
Types of Dominance
 Complete dominance
 Occurs when the phenotypes of the
heterozygote and dominant
homozygote are identical
 Codominance
 In codominance
 Two dominant alleles affect the
phenotype in separate, distinguishable
ways

 The human blood group is an example

of codominance

18.8
18.9
 In Incomplete Dominance
 The phenotype of F1 hybrids is somewhere
between the phenotypes of the two parental
varieties

18.8
 Pleiotropy
 In pleiotropy
 A gene has multiple phenotypic effects

18.10
 Epistasis
 In epistasis
 A gene at one locus alters the
phenotypic expression of a gene at a
second locus

18.10
 BbDd BbDd

Epistas
is

18.10
 Polygenic Inheritance
 Many human characters vary in the
population along a continuum and
are called quantitative characters

 One phenotype is influenced by

multiple genes

18.10
 Polygenic Inheritance

 An additive effect
of two or more
genes on a single
phenotype

18.10
 Multifactorial characters

 Are those that are influenced by

both genetic and environmental
factors
 Examples:
 Heart Disease
 Type II Diabetes
 Many Cancers
18.13
 Pedigree Analysis
 A pedigree
 Is a family tree that describes the
interrelationships of parents and
children across generations

18.11
 Pedigree Analysis

18.11
Cystic Fibrosis
 Symptoms of cystic fibrosis include
 Mucus buildup in the some internal
organs
 Abnormal absorption of nutrients in
the small intestine
 Sickle-Cell Disease
 Sickle-cell disease
 Affects one out of 400 African-Americans
 Is caused by the substitution of a single amino
acid in the hemoglobin protein in red blood cells
 Symptoms include
 Physical weakness, pain, organ damage, and
even paralysis