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INTRODUCTION
As early as 1806 , a persistent inflammatory process following such an infection (eg, diphtheria) of the myocardium led to progressive cardiac damage and dysfunction In 1837, the term myocarditis was first introduced as inflammation or degeneration of the heart by postmortem Endomyocardial biopsy in 1980 allows the sampling of human myocardial
INTRODUCTION
Studies suggest that myocarditis is a major cause of sudden(20%), unexpected death in adults less than 40 years of age
Prospective and retrospective studies have identified myocardial inflammation in 1 to 9 percent of routine postmortem examinations.
CAUSATION
A large variety of infections,
systemic diseases, drugs, and toxins have been associated with the development of this disease
Viruses, bacteria, protozoa, and even worms have been implicated as infectious agents.
Pathophysiology
Several mechanisms of myocardial damage (1) Direct injury of myocytes by the infectious agent (2) Myocyte injury caused by a toxin such as that from Corynebacterium diphtheriae
Pathophysiology
Triphasic disease process Phase I: Viral Infection and Replication Phase 2: Autoimmunity and injury Phase 3: Dilated Cardiomyopathy
Immune-mediated by CD8 lymphocytes and autoantibodies against various myocyte components Antigenic mimicry, the cross reactivity of antibodies to both virus and myocardial proteins Myocyte injury may be a direct
Clinical Findings
Symptoms and Signs - Patients(59%) frequently present days to weeks after an acute febrile illness, particularly a flu-like syndrome - Myocarditis is most commonly asymptomatic, with no evidence of left ventricular dysfunction - fever, malaise, fatigue, arthralgias, myalgias, and skin rash. -Cardiac symptoms may result from systolic or diastolic left ventricular dysfunction or from tachyarrhythmias or bradyarrhythmias
Clinical Findings
Symptoms and Signs - Chest discomfort(35%) is a common symptom and is typically pericardial in nature - Myocarditis may present as sudden death, as a result of malignant ventricular arrhythmias or complete heart block - -Systemic and pulmonary thromboemboli have also been noted.
Clinical Findings
Physical Examination -Tachycardia, hypotension, fever and tachycardia may be disproportionate to the degree of fever -Bradycardia is seen rarely, and a narrow pulse pressure is occasionally detected -Murmurs of mitral or tricuspid regurgitation are common , S3 and S4 gallops may also be heard. -Distended neck veins, pulmonary rales,
Diagnostic Studies
Electrocardiography -The most common abnormality is sinus
tachycardia. - may show ventricular arrhythmias or heart block, or it may mimic the findings in acute myocardial infarction or pericarditis. -Relations between these clinical and laboratory findings
Diagnostic Studies
Chest radiograph
-Mild to moderate cardiomegaly from dilatation of the left or right ventricular cavity -The cardiac silhouette may also be globular when a pericardial effusion is present - Venous congestion and pulmonary edema may be seen in more severe cases
Diagnostic Studies
Echocardiography
-myocardial contractility , chamber sizes , valvular function -Left ventricular systolic dysfunction, regional wall motion abnormalities , global hypokinesis - LV may be normal in size or minimally enlarged -Mitral or tricuspid regurgitation
Diagnostic Studies
-helpful in demonstrating abnormalities of diastolic filling that mimic restrictive cardiomyopathy and indistinguishing ventricular dilatation from pericardial effusion -monitor the course of the illness and to evaluate therapy Radionuclide ventriculography -provides accurate estimates of chamber volumes, as well as left and right ventricular ejection fractions
Diagnostic Studies
Myocardial imaging -Gallium-67 imaging
-> active inflammation of the myocardiumand pericardium -Indium-111 monoclonal antimyosin antibody imaging -> detecting myocyte injury in patients -Contrast media-enhanced MRI ->detecting myocardial inflammation
Diagnostic Studies
Cardiac catheterization -elevated left ventricular end-diastolic pressure, a depressed cardiac output, and increased ventricular volumes -Coronary angiogram typically demonstrates normal coronary arteries.
Diagnostic Studies
Endomyocardial biopsy - gold standard for the diagnosis of myocarditis -Dallas criteria (an inflammatory infiltrate of the myocardium +injury to the adjacent myocytes) -borderline myocarditis is made when the infiltrate is not accompanied by myocyte injury
Normal Myocardium
Borderline Myocarditis
Active Myocarditis
Others test
elevated erythrocyte sedimentation rate (ESR) , mild to moderate leukocytosis CPK-MB , Cardiac troponin-I Other laboratory analyses that may be useful include a Mono-spot test, Epstein-Barr virus titers, hepatitis
Prepared by :
H3 group (2010) SY 2010-2011 Second semester (university of the cordilleras college of nursing)
References
Advances in the understanding of myocarditis. Circulation 2001;104:1076. Feldman AM, McNamara D: Myocarditis. N Engl J Med 2000;19:1388. Diagnosis and presentation of fatal myocarditis Human Pathology (2005) 36, 1003 1007