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Physiology
Approximately 60% of lean body weight is water Two-thirds of the body water is intracellular and the remainder one-third is extracellular Most of the extracellular fluid is in the interstitial space Only about 5% of total body water is in blood plasma The normal blood volume of an adult is about 5 litre
Oedema
It is the abnormal (or excess) collection of fluid in the interstitial spaces or body cavities Hydrothorax, hydropericardium and hydroperitoneum are fluid collections in the pleural, pericardial and peritoneal cavities respectively. The last one is more commonly called ascites
Oedema or fluid accumulation in the subcutaneous tissue; it is called pitting oedema as pressure with the finger-tip in the skin and soft tissue produces depression
Marked oedema associated with inflammation of the larynx narrowing the airways; a life-threatening condition
Bilateral pleural effusion, here the fluid is serosanguinous i.e., mixed with blood
Oedema
According to distribution, it can be generalized or localized Anasarca means severe and generalized oedema with profound subcutaneous tissue swelling Pitting oedema: when finger pressure on an oedematous skin and soft tissue produces a pit or depression due to displacement of the interstitial fluid Oedema fluid may be transudative or exudative in nature
Mechanism of oedema
The major factors that govern movement of fluid between vascular and interstitial spaces are the opposing effects of vascular hydrostatic pressure and plasma colloid osmotic pressure (C.O.P) mostly exerted by serum albumin The vascular hydrostatic pressure (H.P) tends to push fluid out of the blood vessel whereas the plasma C.O.P keeps it inside
Mechanism of oedema
Normally the H.P at the arteriolar end of capillary bed is about 32 mm of Hg and at the venous end is about 12 mm of Hg and the average plasma COP is 25 mm of Hg So there is outflow of fluid into the interstitium at the arteriolar end that is balanced by the inflow at the venous end of the microcirculation A small leftover amount of interstitial fluid is usually removed by the lymphatics
Blood pressure and colloid osmotic forces in the normal microcirculation; red arrow indicates the blood pressure ( about 32 mm of Hg at the arterolar end and 12 mm of hg at the venous end) & green arrow the colloid osmotic force (average 25 mm of Hg in the capillary bed)
Mechanism.
So, either increased capillary pressure or decreased colloid osmotic pressure can result in increased interstitial fluid i.e., oedema As the interstitial fluid pressure increases, tissue lymphatics remove much of the volume ultimately returning it to the circulation If the ability of the lymphatics to drain tissue is exceeded, persistent tissue oedema results
In inflammation increased vascular hydrostatic pressure and reduced plasma colloid osmotic pressure in the microcirculation results in oedema
Categories..
Reduced Plasma Osmotic Pressure (Hypoproteinemia) Protein-losing glomerulopathies (Nephrotic syndrome) Liver cirrhosis (Ascites) Malnutrition (Kwashiorkor) Protein-losing gastroenteropathy Lymphatic Obstruction Inflammatory Neoplastic Postsurgical Postirradiation
Categories..
Sodium Retention Excessive salt intake with renal insufficiency Increased tubular reabsorption of sodium in Renal hypoperfusion Increased renin-angiotensin-aldosterone secretion Inflammation Acute inflammation Chronic inflammation Angiogenesis
Events leading to oedema in heart failure, or with qed plasma osmotic pressure, as in nephrotic syndrome. ADH, antidiuretic hormone; GFR, glomerular filtration rate
Lymphatic Obstruction
Usually produces localized oedema Can result from inflammatory or neoplastic obstruction.The parasitic infection filariasis causes massive lymphatic and lymph node fibrosis of the inguinal region. The resulting extreme oedema of the external genitalia and the lower limbs is called elephantiasis Involvement of the axillary lymph nodes by breast cancer, or by scarring following their surgical removal or radiation therapy may cause severe oedema of the arm
Morphology of oedema
Most easily recognized grossly Microscopically oedema fluid manifests as subtle cell swelling,with clearing and separation of the extracellular matrix elements Most commonly seen in subcutaneous tissues, affected area pits on pressure Subcutaneous oedema may be diffuse, or may be more prominent at the site of highest hydrostatic pressures typically influenced by the gravity and is called dependent oedema
Morphology
Dependent oedema ( is evident in the legs when standing, over the sacrum when recumbent) is a prominent feature of congestive heart failure particularly of the right ventricle Oedema of renal cause is usually more severe than cardiac oedema and is generalized in distribution but initially may manifest in the face around the eyelids as periorbital oedema
Morphology
Pulmonary oedema is commonly seen in left ventricular failure, also in renal failure, adult respiratory distress syndrome, pulmonary infections and hypersensitivity reactions. The lungs are heavy, 2 to 3 times their normal weight and sectioning reveals frothy blood-tinged fluid composed of air, oedema fluid and extravasated red blood cells
Morphology
Oedema of the brain may be localized to sites of injury like in abscess, neoplasm or may be generalized as in encephalitis, hypertensive crisis, or obstruction to the brains venous outflow. Trauma may cause generalized or local oedema. With generalized oedema, the brain is grossly swollen with narrowed sulci and distended gyri showing signs of flattening against the unyielding skull
Hyperemia
A local increased volume of blood in a particular tissue It is an active process resulting from increased tissue inflow because of arteriolar dilation, as in skeletal muscle during exercise, or at sites of inflammation The affected tissue is redder because of engorgement with oxygenated blood Morphology: Cut surfaces of the hyperemic tissue are hemorrhagic and wet
Congestion
A local increased volume of blood in a particular tissue Is a passive process resulting from impaired outflow from a tissue May be systemic, as in cardiac failure, or may be local, as in isolated venous obstruction The tissue has a blue-red color (cyanosis) due to accumulation of deoxygenated blood
Congestion
Congestion of capillary beds is closely related to the development of oedema, so congestion and oedema commonly occur together In long-standing congestion, the tissue becomes hypoxic due to poorly oxygenated blood which can result in parenchymal cell degeneration or death Capillary rupture at these sites may cause small foci of hemorrhage; breakdown and phagocytosis of red cell debris may result in small clusters of hemosiderin laden macrophages ( heart failure cells)
Congestion
Chronic pulmonary congestion is seen in long-standing heart failure Chronic passive congestion of liver is seen in right heart failure
Hemorrhage
It means extravasation of blood due to vessel rupture Rupture of a large vessel is due to trauma, atherosclerosis, inflammatory or neoplastic erosion of the vessel wall The hemorrhagic lesions are named as follows * Hematoma: collection of hemorrhagic fluid within a tissue. May be relatively insignificant (as in bruise) or fatal causing death ( e.g., a massive retroperitoneal hematoma from ruptured aortic aneurysm)
Hemorrhage
Petechiae: minute 1 to 2 mm hemorrhages into skin, mucous membranes or serosal surfaces. Are found in locally raised intravascular pressure, low platelet count, defective platelet function, or clotting factor deficit Purpura: slightly larger ( 3 mm) hemorrhages than petechiae, may have same pathology and also trauma, vasculitis, or oed vascular fragility
Hemorrhage
Ecchymoses: larger (> 1 to 2 cm) subcutaneous hematomas, typical after trauma; undergoes progressive color changes from red-blue (hemoglobin) to blue-green (bilirubin) to gold-brown (hemosiderin) Hemothorax, hemopericardium, hemoperitoneum and hemarthrosis: are large collections of blood in one or another of the body cavities
Clinical importance
It depends on the volume, rate and site of blood loss Volume: rapid removal of upto 20% of the blood volume or slow loss of even larger amount may have little impact; but greater losses may produce hypovolemic shock Site: bleeding that is trivial in subcutaneous tissue may cause death if located in brain Rate: chronic or recurrent external blood loss causes iron deficiency anemia whereas internal bleeding may give rise to jaundice
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