DR ANTHONY MELVIN CRASTO Ph.D Organic Chemistry, 25yrs+exp. In Process Research, million hits on google.

COMPANY IS LOCATED IN NAVIMUMBAI, INDIA http://www.glenmark-generics.com/ EMAIL- amcrasto@gmail.com Currently working with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) and leading a team of scientists in developing APIs for regulated markets. This involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing. Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projects

Process Development :Providing guidance and support for process development for challenging of patents in regulated market. Design patent non-infringing scalable synthetic routes/process and scale-up of API s Bench and Pilot scale synthesis transformations in hands on Optimization of the process, ie,developing industrially feasible process. Preparation of PDR, filing of patent and DMF Lead a group of Scientists and Group Leaders(for docs). Skill sets:- Technical skills: Synthesis: Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant Conducted various reactions at laboratory and production scales. Synthesized various classes of compounds. Experienced to work under cGMP condition Documentation: Literature survey: well conversant with the use of Sci Finder and Internet search techniques. Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.). Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products. Soft skills:Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening

To carry out research and development activity in the field of Organic Chemistry, to make profit for the organization, motivate, guide & lead a team of scientists, conduct literature search, identify and execute new/novel routes for the synthesis, scale up from grams to kilo levels in lab., conduct pilot trials and assist in production upto ton levels. Carry out impurity profiles and assist in dossier writing. All the above being done keeping in mind the regulatory, safety, environmental issues. To keep in mind IPR issues and draft patents , Commercial aspects taken care are the time schedules, quality parameters and cost factors. All this with a view of non infringement and confidentiality. Simultaneously develop business acumen and convert to profits.file DMFS in US and EU, file patents and contribute to intellectual property

1 Currently working as Principal Scientist, Process research(Bulk Actives) with GLENMARK PHARMACEUTICALS LTD research centre, API division at Mahape ,Navi Mumbai, India job involves research and development work on APIs from lab to commercial production, support for DMF filing, in the process develop novel non infringing routes and file patents,(dec05-present) 2 Worked as Sr Manager R&D with Innovassynth technologies Limited, Khopoli, India (formerly IOC ltd) and led a team of 20 chemists for the custom synthesis business in the area of drugs, organic intermediates, specialty chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.(may03-dec05----2 yrs 7 months)

3 Worked as a Manager (R&D) at RPG Life Sciences Ltd ( formerly Searle India ltd). Thane Belapur. INDIA The job involved all aspects of synthesis and commercialization from research lab to production, including third party activities. (Oct. 1997- may2003, 5 years 6 months ) 4 Worked as an Executive, process development at German multinational Hoechst Marion Roussel Ltd, (NOW SANOFI-AVENTIS)Mulund, Mumbai, India in the QA dept, GMP section (Feb.1997 oct. 1997, 8 months) 5 Worked as an Executive,QA/GMP at a German multinational Hoechst Marion Roussel Ltd, Mulund, Mumbai, India in the Process Development Team. (Jan1993 - Jan1997, 4 years) 6 Carried out Synthetic Research work as a Management trainee (R&D) at an American multinational Searle India ltd, Research and development centre, Thane, India (Now RPG Life Sciences Ltd) (May 1991 to Dec. 1992, 1 year 7 months) 7 Worked as Indian Organic chemicals research fellow at UDCT Matunga, Mumbai, for PhD programme(organic chemistry) on the topic Synthesis of novel pyrethroids analogues . Simultaneously did project work for IOC.(1987-1991, 4 years)

Title:AMORPHOUS BAZEDOXIFENE ACETATE AND PREPARATION THEREOF Authors: A M CRASTO Ref. No: US 20100310870 Year: 2010 The present invention relates to amorphous form of bazedoxifene acetate and a process for the preparation thereof. A PROCESS FOR THE PREPARATION OF ATOVAQUONE CRYSTALLINE Authors: A M CRASTO ET AL Ref. No: 1742/MUM/2007 A Year: 2009 The present invention provides a process for the preparation of Atovaquone in a pure polymorphic form characterized by an X-ray powder diffraction pattern with peaks at about 7.0, 9.7, 14.2, 14.8,...

Process for the preparation of tadalafil Authors: A M CRASTO Ref. No: EP2004644 (A1) Year: 2008 Process for the preparation of atovaquone Authors: A M CRASTO Ref. No: US20090105350 Year: 2008 Amorphous eprosartan mesylate and process for the preparation thereof Authors: A M CRASTO Ref. No: United States Patent Application 20080014263 Year: 2007

PROCESS FOR THE PREPARATION OF TADALAFIL Authors: A.M. CRASTO Year: 2007 A PROCESS OF PREPARATION OF METHANAMINE-N-[4(3,4DICHLOROPHENY)-3,4-DIHYDRO-1(2H)NAPHTHALENYLIDENE Authors: A M CRASTO ET AL Ref. No: Application No.243/BOM/1999 A Year: 1999 A process for the preparation of methanamine-N-[4(3,4-dichlorophenyl)]-3,4dihydro-1(2H)-naphthalenylidene, a critical intermediate in the synthesis of.................. Heterocyclic Analogues of Pyrethroids Authors: A .M. Crasto and S. Seshadri Thirteenth International Congress of Heterocyclic Chemistry , held at Corvallis, Oregon (U.S.A.) Abstract No. GE-11-129 ; 1991

Amorphous frovatriptan succinate and process for the preparation thereof Authors: A M CRASTO Year: 2007

SYNTHESIS OF NOVEL PYRETHROID ANALOGUES---THESIS Authors: A.M. CRASTO MUMBAI UNIVERSITY, 1991 Supervisor: PROF S . SESHADRI

Synthesis of Novel & Chloromethyl esters via Regiospecific ring opening reactions of aryl glycidyl ethers with acid chlorides and the synthesis of alpha- morpholino methyl and alpha- cyano methyl esters Authors: A. M. Crasto and S. Seshadri Paper presented at the 3rd Research Scholars Meeting, Indian Chemical Society, Feb. 1991. , TIRUPATI, INDIA; 1988

A.M.CRASTO MEDICINAL CHEMISTRY ANTHONY CRASTO GREEN CHEMISTRY Anthony Crasto heterocyles ANTHONY CRASTO MOLECULES Anthony Crasto mycv ANTHONY CRASTO ORGANIC CHEMISTRY ANTHONY CRASTO PHARMACEUTICALS ANTHONY CRASTO REACTIONS ANTHONY CRASTO REAGENTS Anthony Crasto Scaleup ANTHONY CRASTO SOURCING ANTHONY CRASTO SPECTROSCOPY Anthony Crasto Stereochemistry

ANTHONY MELVIN CRASTO ( Ph.D) Shared with everyone in the worldANTHONY MELVIN CRASTO , ORGANIC CHEMISTRY RELATED LINKS/site/amcrasto/ ANTHONY MELVIN CRASTO CV Shared with everyone in the world/site/anthonymelvincrastocv/ POLYMORPHISM IN ORGANIC CHEMISTRY Shared with everyone in the world/site/polymorphisminorganicchemistry/ R & D for GM, VP

ANTHONY http://groups.google.com/group/organic-processdevelopment http://www.linkedin.com/groupRegistration?gid=3554645 http://www.researchgate.net/group/ORGANIC_PROCE SS_DEVELOPMENT/ http://groupspaces.com/ORGANICPROCESSDEVELOPME NT2/announcements/

COPY AND PASTE THESE LINKS ON YOUR BROWSER TO GET HOLD OF SITES

Linkedin page http://in.linkedin.com/in/amcrasto Researchgate http://www.researchgate.net/profile/Anthony_Crasto _Dr/ SiliconIndia http://www.siliconindia.com/profiles/Anthony-MelvinCrasto-PhD-5G2yZBSx.html Diigo http://www.diigo.com/user/amcrasto Mashable http://mashable.com/follow/people/anthony-melvincrasto/

Remember when you discriminate you are pumping jet feul into the flight of dreams

THANKS