Beruflich Dokumente
Kultur Dokumente
Consists of two lobes connected by an isthmus and surrounded by a capsule (double layers of CT).
Develops as an evagination from the wall of the pharynx Contains two types of hormonesecreting cells:
1. 4/2/12
4/2/12
4/2/12
4/2/12
Synthesis of thyroglobulin Release into follicle lumen Iodination Storage as colloid Endocytosis of colloid in response to secretory stimulus (TSH from adenohypophysis)
6.
Follicle cells are low cuboidal when hypoactive; high cuboidal/low columnar when the gland is active; Hyperactive thyroid has little or no colloid in lumen of follicles. Follicle cells contain large nuclei, basophilic cytoplasm with fine granules, and numerous mitochondria, RER and lysosomes
4/2/12
Parathyroid Glands
Lie on border of thyroid, usually 4 glands in humans (range is 2-6); derived from endoderm of pharyngeal pouches. Covered with a thin capsule and also enclosed in fascia of thyroid; septa extend inward from capsule, divide gland incompletely into lobules; septa carry blood vessels, lymphatics, nerves Glandular epithelium consists of 2 cell types:
Chief Cells = small, round, pale-staining cells with a spherical nucleus and indistinct cell borders. Secrete Parathyroid hormone
Oxyphil Cells = less common, larger with acidophilic cytoplasm, smaller darker nucleus, numerous mitochondria; increase in number after puberty. May represent non-secretory chief cells, but precise function 4/2/12
= CT septa
4/2/12
Adrenal Glands
Paired glands located at cranial pole of each kidney; composed of 2 histological regions: Cortex = outer region, secretory cells derived from mesoderm, produce corticosteroids Medulla = inner region, secretory cells derived from neural crest tissue, produce catecholamines (epinephrine, norepinephrine) 4/2/12
4/2/12
Adrenal Cortex
Composed of 3 zones (outside to inside): Zona glomerulosa = narrow zone immediately beneath capsule (~15% of cortex), cells arranged into rounded clumps Consists of pyrimidal or columnar cells with dark-staining spherical nuclei, acidophilic cytoplasm with some basophilic material, cytoplasm 4/2/12
Adrenal Cortex
Zona fasiculata = thickest layer (~78% of cortex) Consists of irregular cuboidal/polyhedral cells arranged in long radial cords; bordered by fenestrated capillaries. Cells contain vesicular nuclei and basophilic cytoplasm with numerous lipid droplets (droplets larger than in zona glomerulosa) 4/2/12
Adrenal Cortex
Zona reticularis = composes ~7% of cortex volume Cells form anastomosing network, separated by fenestrated capillaries Cells in this region are smaller, the cytoplasm contains fewer lipid droplets and the nuclei are deeper-stained Produces some glucocorticoids and very small amounts of sex hormones (dihydroepiandrosterone; 4/2/12
4/2/12
4/2/12
Adrenal Medulla
Consists of anastomosing cords of cells known as chromaffin cells (due to specific staining of secretory granules with Chromium salts) Secrete epinephrine (adrenaline), norepinephrine Secretory cells of medulla innervated by sympathetic preganglionic fibers, so they are functionally equivalent to sympathetic ganglion cells. 4/2/12
4/2/12
4/2/12
Pineal Body
Cone-shaped body attached by a stalk to the roof of the 3rd ventricle of the brain Produces melatonin which exerts a suppressive effect on gonadal function and regulates circadian and circannual rhythms, among other actions Pia mater forms capsule around pineal body 4/2/12
Pinealocytes = epithelial secretory cells (melatonin), irregularly shaped with branching processes; palestaining cells with a large nucleus Glial Cells = serve as supporting network; fewer in number, possess elongated deeply stained nucleus Extracellular Concretions = lamellated bodies of calcified organic matrix; occur mainly in capsule and 4/2/12
4/2/12
Lamprey = rostral and proximal pars distalis, pars intermedia and pars nervosa form neurointermediate lobe; no pars tuberalis present Teleost = tendency to localize cellular types in specific regions; also have rostral and proximal pars distalis, neurointermediate lobe, but positions are reversed from mammalian condition with neurohypophysis anterior, 4/2/12
Tele ost
pp d
Lampr ey
NI L
rp d
Repti le p.
n.
Anur an
p. i.
4/2/12
Bir d
Ultimobranchial Bodies = derived from ventral portion of 5th pharyngeal pouch, present in nonmammalian vertebrates
= Ultimobranchi al bodies
= Parathyroi d
4/2/12
Comparative Adrenal
Primitive Condition = diffuse tissue Advanced Condition = Discrete glands with discrete regions of cortical and chromaffin tissue; become associated with cranial pole of kidney
4/2/12
Bir d
Crocod ile
Sna ke
Liza rd
Mamm al
Salaman der
Anu ra
Lungf ish
Holost ean
Post cardinal veins
Elasmobr anch
Cyclosto me
4/2/12