Skeletal muscle contraction

All images in this document is removed due to copyright restriction

Ahmad Aulia Jusuf Nani Cahyani Sudarsono

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Fungsi utama otot sebagai penggerak tubuh melalui kontraksi serat otot yang menghasilkan kekuatan/tegangan otot (muscle tension) Anatomi mikroskopik otot hubungannya dengan 3 unit organisasi:
Konduksi sarkolema Kontrol retikulum sarkoplasmik Kontraksi miofibril

Dasar molekuler kontraksi otot: proses sliding of myofilaments secara berulang pada keadaan cukup tersedia ATP dan ion Ca Metabolisme kontraksi otot. Jenis serat otot serta perannya dalam gerakan tubuh. Pengendalian gerakan tubuh.

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

muscle moves the body

through skeletal muscle contraction that produce muscle tension

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Sarcomere

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

molecular basis of muscle contraction:

repeated sliding of myofilaments at sufficient ATP and Ca

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscle contraction animation:

San Diego State University College of Sciences

Based in part on Color Atlas of Physiology, Agamemnon Despopoulos, Stefan Silbernagl Thieme Medical Publishers, Inc. , 1991, New York

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

http://home.earthlink.net/~dayvdanls/biology1_2/physiolect8.htm

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Metabolism for muscle contraction

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscle Metabolism: Energy for Contraction

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Energy for Contraction

Vander, Sherman, Luciano's Human Physiology: The Mechanisms of Body Function, 9/e

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Energy for Contraction: ATP & Phosphocreatine

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscle Proteins

(http://www.chemsoc.org/exemplarchem/entries/kscott/images/titin.gif)

(http://www.chemsoc.org/exemplarchem/entries/kscott/images/titin.gif)

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved

Dystrophin Function Protein similarity a-actinins spectrins Functional domains amino terminus - 240 aa, binds F-actin coiled-coiled rod - 2400 aa, longest section provides flexibility and elasticity cysteine-rich - 280 aa, required for membrane attachment to b-dystroglycan carboxy terminus - 420 aa, contains potential phosphorylation sites, binds to syntrophins Function

mechanical reinforcement of sarcolemma (in skeletal muscle)

signal transduction (control of muscle fiber caliber and size) anchor or stabilizer of dystroglycans and sarcoglycans

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved

Copyright 2001-2004, E.C. Niederhoffer. All Rights Reserved

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Metabolic Pathways Glucose glycolysis (TCA cycle) glycogenolysis (TCA cycle) Fatty acids b-oxidation (TCA cycle)

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Metabolic Pathways

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Metabolic Pathways

Metabolic Pathways Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Nelson, D. L., and M. M. Cox. 2000. Lehninger principles of biochemistry, 3rd ed., p. 604. Worth Publishers, New York.

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Role of Calcium Muscle contraction troponin C Glycogen breakdown

calmodulin (activates phosphorylase b kinase)

Citric acid cycle activation pyruvate dehydrogenase complex isocitrate dehydrogenase

a-ketoglutarate dehydrogenase

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Role of Calcium

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Muscle fiber and its role in movement

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Jenis serat otot serta perannya dalam gerakan tubuh

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Fiber Contraction Speed: Fast & Slow Twitch muscle fibers

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

RED muscle fiber

Glycogen? Myoglobin? Capillary? Diameter? << >> >> <<
Metabolism? Myosin ATPase activity? Time to develop max tension? Ca++-ATPase activity in SR? Contraction duration? Endurance? Use?

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

WHITE muscle fiber

Glycogen? Myoglobin? Capillary? Diameter? >> << << >>
Metabolism? Myosin ATPase activity? Time to develop max tension? Ca++-ATPase activity in SR? Contraction duration? Endurance? Use?

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Pengendalian gerakan tubuh

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Control of movement

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Graded Muscle Responses

Graded muscle responses are:
Variations in the degree of muscle contraction Required for proper control of skeletal movement

Responses are graded by:

Changing the frequency of stimulation Changing the strength of the stimulus

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Treppe: The Staircase Effect

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Figure 9.16

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Stimulus Intensity and Muscle Tension

Elaine N. Marieb Human Anatomy & Physiology, Sixth Edition

Figure 9.15 (a, b)

Copyright 2004 Pearson Education, Inc., publishing as Benjamin Cummings

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

Recruitment of Fibers: Graduated Force

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Coordinating the Fibers: Summation to Tetanus

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Figure 12-17: Summation of contractions

Muscloskeletal module Faculty of Medicine Universiaas Indonesia December 2006

KONTRAKSI OTOT
SARAF MOTORIK

CROSS BRIDGE

POWER STROKE GAYA MEKANIK

FREKUENSI & INTENSITAS PERANGSANGAN GERAKAN TUBUH