Hormone und ihre Rezeptoren in Brustkrebszellen: [Fragment, Androgenrezeptoren]

Stand / Letzte Aktualisierung durch Elisabeth Rieping 05.01.2006

Stichworte: Androgenrezeptoren

Brustkrebszellen besitzen Rezeptoren, also Kontaktmoleküle für für Hormone.

Sehr bekannt sind die Rezeptoren für Östrogene und für Progesteron. Bei der Operation
des Tumors wird auf diese Rezeptoren standardmäßig untersucht. Die Östrogen-
Rezeptoren werden durch Kontakte mit Östrogenen so beeinflusst, dass sie die Teilung
der Krebszellen stimulieren können. Durch die Anti-Hormonbehandlung AHB versucht
man, diese Stimulierung unmöglich zu machen.

Weniger bekannt ist, dass Brustkrebszellen auch Androgenrezeptoren enthalten. Und weil
das so wenig bekannt ist, will ich damit anfangen, um es bekannter zu machen.

Androgenrezeptoren in Brustkrebszellen
Etwa siebzig Prozent der Brustkarzinome in der hier beschriebenen Untersuchung wiesen
Androgenrezeptoren auf. Wobei die Frauen, deren Tumore nach einem Rückfall noch
Androgenrezeptoren aufwiesen, längere Überlebenszeiten hatten (Schippinger W 2006).

Literatur, die ich noch verarbeiten will und hier erst mal sammle.
Zagarianakou P 2006 apocrine ~ Sekretionsform bei
Drüsen, bei der das Sekret durch
Abschnürung des äußersten
The enigmatic nature of apocrine breast lesions. Zellteils abgeschieden wird, z. B.
Duft- und Milchdrüsen
Die rätselhafte Natur der apokrinen Brustläsinonen.

Zagorianakou P, Zagorianakou N, Stefanou D, Makrydimas G, Agnantis NJ.

Department of Pathology, University of Ioannina, Medical School, University Campus,

P.O. Box 1186, 45110, Ioannina, Greece, nagnanti@cc.uo.

Hormone und ihre Rezeptoren in Brustkrebszellen von Elisabeth Rieping (Fragment) 1

 “Epithelial cells of fetal breast glandular structures, at the third trimester of pregnancy (28
weeks), produce GCDFP-15, in the absence of specific apocrine morphology. Apocrine
epithelium of the breast may be a normal process of differentiation rather than a result of
metaplasia, and it has been demonstrated that it is estrogen-receptor, progesterone-
receptor and bcl-2 negative, but androgen-receptor (AR) positive. The significance of AR
expression in apocrine epithelium is uncertain. Apocrine epithelium is seen in a wide
spectrum of breast entities, ranging from benign lesions to invasive carcinoma. Breast
cancer accounts 32% of all cancer cases among women and is the most common type of
cancer in women. Little is known about breast carcinogenesis. Widely, it is accepted that
breast cancer, like most other type of cancer, is being developed through the accumulation
of genetic aberrations. Apocrine epithelium may reflect instability of the breast
epithelium, creating an environment favouring further oncogenic alterations. In the last
decade, several lines of evidence support the idea that some breast benign epithelial
apocrine lesions are clonal lesions and may be considered as truly pre-malignant or
precursors of breast carcinoma. Apocrine changes in many cases do not present any
diagnostic difficulty; on the other hand, apocrine proliferations with cytologic atypia can
be particularly difficult and challenging. The purpose of this study is to collect and
highlight the areas of consensus in the literature as well as the controversial areas
concerning the apocrine epithelium of the breast.”

DHEA-Induced Antiproliferative Effect in MCF-7 Cells Is Androgen- and

Estrogen Receptor-Independent.

Gayosso V, Montano LF, Lopez-Marure R.

Departmento de Biologia Celular, Instituto Nacional de Cardiologia "Ignacio Chavez,",

UNAM, Mexico City, Mexico.

“Dehydroepiandrosterone, an adrenal hormone derived from cholesterol, can be

metabolized to estrogens (estradiol) and androgens (testosterone). In this study, we
evaluated whether the antiproliferative effect induced by dehydroepiandrosterone in
MCF-7 cells (an estrogen-dependent breast cancer cell line) is direct, or indirect, through
its conversion to estradiol or testosterone. Although dehydroepiandrosterone had an

Hormone und ihre Rezeptoren in Brustkrebszellen von Elisabeth Rieping (Fragment) 2

 antiproliferative effect at supraphysiologic concentrations, when it was used at
physiologic concentrations, it increased the proliferation of MCF-7 cells. 17beta-estradiol
induced an increase in MCF-7 cell proliferation at physiologic concentrations, whereas
testosterone had a weak inhibitory effect at 100 muM. Dehydroepiandrosterone sulfate
(its inactive sulfate ester) had no effect upon the cell cycle. Dehydroepiandrosterone-
induced antiproliferative and proliferative effects were not blocked by inhibitors of
androgen or estrogen receptors, thus indicating that its effect is secondary to a direct
interaction with a "putative" receptor rather than a conversion into steroid hormones.
These results suggest that dehydroepiandrosterone could be used at supraphysiologic
concentrations in the treatment of breast cancer (Gayosso V 2006).

archive.org: http://web.archive.org/web/*/http://www.erieping.de/Hormonrezeptoeren.htm

Hormone und ihre Rezeptoren in Brustkrebszellen von Elisabeth Rieping (Fragment) 3