Einführung in die Genetik

Prof. Dr. Kay Schneitz (EBio Pflanzen)

http://plantdev.wzw.tum.de
kay.schneitz@tum.de
Twitter: @PlantDevTUM, #genetikTUM

Prof. Dr. Claus Schwechheimer (PlaSysBiol)

http://wzw.tum.de/sysbiol
claus.schwechheimer@wzw.tum.de
 Genetik - Bio/Ernährung (ZoomQA um 09:15 Uhr)
1 Einführung 20. 04. 20 KS
2 Struktur der DNA und Chromosome 27. 04. 20 KS
3 Transkription/Translation 04. 05. 20 KS
4 Transmission der DNA während der Zellteilung 11. 05. 20 KS
5 Vererbung von Einzelgenveränderungen 18. 05. 20 KS
6 Genetische Rekombination (Eukaryonten) 25. 05. 20 KS
7 Regulation der Genexpression 08. 06. 20 KS
8 Rekombinante DNA-Technologie 15. 06. 20 CS
9 Kartierung/Charakterisierung ganzer Genome 22. 06. 20 CS
10 Genmutationen: Ursache und Reparatur 29. 06. 20 CS
11 Veränderungen der Chromosomen 06. 07. 20 CS
12 Transposons bei Eukaryonten 13. 07. 20 CS
13 Genetische Analyse biologischer Prozesse 20. 07. 20 CS
14 Regulation der Zellzahl - Onkogene (Klausur) 27. 07. 20 CS
2
 Genetik - MBT/BC (Zoom QA um 10:30 Uhr)
1 Einführung 20. 04. 20 KS
2 Struktur der DNA und Chromosome 27. 04. 20 KS
3 Transkription/Translation 04. 05. 20 KS
4 Transmission der DNA während der Zellteilung 11. 05. 20 KS
5 Vererbung von Einzelgenveränderungen 18. 05. 20 KS
6 Genetische Rekombination (Eukaryonten) 25. 05. 20 KS
Gen. Rekombination (Bakterien/Viren)/
7/8 08. 06. 20 KS
Regulation der Genexpression
9 Rekombinante DNA-Technologie 15. 06. 20 CS
10 Kartierung/Charakterisierung ganzer Genome 22. 06. 20 CS
11 Genmutationen: Ursache und Reparatur 29. 06. 20 CS
12 Veränderungen der Chromosomen 06. 07. 20 CS
13 Transposons bei Eukaryonten 13. 07. 20 CS
14 Genetische Analyse biologischer Prozesse 20. 07. 20 CS
15 Regulation der Zellzahl - Onkogene 27. 07. 20 CS
3
 Transposons in eukaryotes
Genetics 13

Based on Chapter 16 (10th ed.) or Chapter 14 (9th edition)

 Discovery of transposons

Structure of transposons - prokaryotes

Class I: Retrotransposons - eukaryotes

Class II: DNA Transposons - eukaryotes

Transposons and genome evolution

The Ds transposable element helps cause breakage

Ds, Dissociator
Unusual phenotypes are caused by the
Ds transposable element

Figure 14-3a
Unusual phenotypes are caused by the
Ds transposable element

Figure 14-3b
Activator transposase catalyzes excision and integration
 Phenotypes produced by transposable elements
in corn kernels
- autonomous and nonautonomous transposons -

Figure 14-4
Structures of transposons
- prokaryotes -
Structural features of composite and simple transposons

Figure 14-6
An R plasmid may contain several transposons
carrying resistance genes

Figure 14-7
Two modes of transposition

Figure 14-9
Replicative transposition of Tn3

Figure 14-10
An inserted element is flanked by a short repeat

Figure 14-8
Class I: Retrotransposons
Retrotransposons have features in common
with retroviruses

Figure 14-12
Life cycle of a retrovirus

Figure 14-11
A retrotransposon is transposed through an
RNA intermediate

Figure 14-13
Demonstration of transposition through an
RNA intermediate

Figure 14-14
Class II: DNA transposons
Activator transposase catalyzes excision and integration
Transposons and genome evolution
Types of transposable elements in the human genome

Figure 14-20

LINE long interspersed element

SINE short interspersed element
Transposable elements in grasses are responsible for
differences in genome size

Figure 14-22
Transposable elements insert into safe havens

Figure 14-23b
Human genes contain many transposable elements

Figure 14-21
What you need to know and understand for the exam
and for your life....
... composite transposons, simple transposons
... transposons and resistance genes
...replicative and conservative transposition
...structure of retrotransposons (gag, pol, env)
...RNA-origin of retrotransposons
...DNA transposons
...DNA transposons in the human genome (LINE, SINE,
Alu)
...Ac/Ds transposons
...safe havens
The end